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Elaborated spectral, modeling, QSAR, docking, thermal, antimicrobial and anticancer activity studies for new nanosized metal ion complexes derived from sulfamerazine azodye

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Abstract

New azodye ligand (H2L) and its relative Cr(III)-, Mn(II)-, Fe(III)-, Co(II)-, Ni(II)-, Cu(II)-, Zn(II)- and Cd(II)-nanosized complexes were prepared. A new synthesized compounds were characterized using spectral (mass, IR, UV–Vis, XRD, and ESR) and analytical (elemental, molar conductance, thermal and magnetic moment measurements) tools. Infrared spectra showed that the ligand behaves as a monobasic bidentate, coordinating with central atoms through carbonyl oxygen and α-hydroxyl group. The geometrical structures of Cr(III) and Fe(III) complexes were found to be in octahedral configuration, whereas Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes have tetrahedral forms. XRD patterns reflect an amorphous appearance of all investigated complexes. TEM images showed nanosized particles and identical distribution over the complex surface. Molecular modeling for the drug ligand and its metal ion complexes were performed using Gaussian09 program to assert on their structural formulae. Some essential parameters were extracted using HOMO and LUMO energies. AutoDock tools 4.2 was used to simulate the interaction process with infected cell proteins to expect the experimental pathway. The inhibition activity of drug ligand and its metal ion complexes was evaluated towards different types of bacteria and fungi through in vitro antimicrobial activities. The antitumor activities of all compounds are straightened towards human liver carcinoma (HEPG2) cell lines. Fe(III) and Co(II) complexes exhibited IC50 of 2.90 and 4.23 µg mL−1, respectively, which means they are more potent anticancer drug than the standard (doxorubicin, IC50 = 4.73 µg mL−1). Therefore, the two complexes may consider promising anticancer drugs.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Mecca, Saudi Arabia

    Fawaz A. Saad, Jabir H. Al-Fahemi, Hoda El-Ghamry, Abdalla M. Khedr, Marwa G. Elghalban & Nashwa M. El-Metwaly

  2. Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt

    Hoda El-Ghamry & Abdalla M. Khedr

  3. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

    Marwa G. Elghalban & Nashwa M. El-Metwaly

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  1. Fawaz A. Saad
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  2. Jabir H. Al-Fahemi
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Saad, F.A., Al-Fahemi, J.H., El-Ghamry, H. et al. Elaborated spectral, modeling, QSAR, docking, thermal, antimicrobial and anticancer activity studies for new nanosized metal ion complexes derived from sulfamerazine azodye. J Therm Anal Calorim 131, 1249–1267 (2018). https://doi.org/10.1007/s10973-017-6598-4

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