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Sodium alendronate used in bone treatment

A complex study on the thermal behavior of the bioactive compound and its binary mixtures with several excipients

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Abstract

The thermally induced interactions of sodium alendronate trihydrate in 1:1 mass ratio binary mixture with talc, silica, magnesium stearate, microcrystalline cellulose, starch, gelatin and mannitol were studied under non-isothermal conditions. The heat flow (HF) signal, obtained by converting the temperature differences (DTA) into power units, was used for detecting the thermally induced events. By all the seven excipients, no thermally induced interactions with alendronate were observed, but the thermal stability of the excipients is very different. The talc and silica, as expected, are very thermostable. By starch, gelatin, and microcrystalline cellulose, the HF signal corresponding to the thermo degradation is over 270 °C, the deamination step of alendronate. The magnesium stearate and mannitol substances are not recommended for solid formulation due to its low thermal stability.

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Acknowledgements

Iulia CEBAN (PhD student) was cofinanced in this work from the European Social Fund through Sectoral Operational Programme Human Resources Development 2007–2013, Project Number POSDRU/187/1.5/S/155559, Competitive Multidisciplinary Doctoral Research in Europe. Paul Albu (PhD) was supported by strategic Grant POSDRU/159/1.5/S/133391.

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Authors and Affiliations

  1. University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, 300041, Timisoara, Romania

    Sorin Cristian Doca & Andrei Anghel

  2. Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, 16 Pestalozzi St., 300115, Timisoara, Romania

    Paul Albu, Iulia Ceban, Gabriela Vlase & Titus Vlase

  3. Departament of Pharmaceutical Sciences, Faculty of Pharmacy, “Vasile Goldis” West University of Arad, 86 L. Rebreanu St., 310414, Arad, Romania

    Paul Albu

Authors
  1. Sorin Cristian Doca
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  2. Paul Albu
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  3. Iulia Ceban
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  4. Andrei Anghel
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  5. Gabriela Vlase
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  6. Titus Vlase
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Correspondence to Paul Albu.

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Doca, S.C., Albu, P., Ceban, I. et al. Sodium alendronate used in bone treatment. J Therm Anal Calorim 126, 189–194 (2016). https://doi.org/10.1007/s10973-016-5619-z

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  • DOI: https://doi.org/10.1007/s10973-016-5619-z

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