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DSC kinetic study of the incompatibility of doxepin with dextrose

Application to pharmaceutical preformulation studies

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Abstract

In the present paper, the physicochemical incompatibility of doxepin with dextrose was evaluated in solid-state mixtures. The compatibility was evaluated using different physicochemical methods such as differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy and mass spectrometry. Non-isothermally stressed physical mixtures were used to study the solid-state kinetic parameters. Different thermal models such as Friedman, Flynn–Wall–Ozawa and Kissinger–Akahira–Sunose were used for the characterization of the drug–excipient mixtures. Overall, the incompatibility of doxepin as a tertiary amine with dextrose as a reducing carbohydrate was successfully assessed. DSC-based kinetic analysis is a simple and fast method in evaluation of different drug–excipient mixtures incompatibility. Finally, it can be recommended to exclude dextrose from doxepin pharmaceutical formulations and also to apply the easy and versatile DSC method in kinetic study of drug–excipient incompatibility.

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Acknowledgements

This paper was extracted from a PhD thesis (No: 91) submitted to faculty of Pharmacy, Tabriz University of Medical Sciences and financially supported by the same University.

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Authors and Affiliations

  1. Department of Pharmaceutical and Food Control, Tabriz University of Medical Sciences, Tabriz, Iran

    Faranak Ghaderi, Mahboob Nemati, Mohammad R. Siahi-Shadbad & Farnaz Monajjemzadeh

  2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Faranak Ghaderi

  3. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mahboob Nemati

  4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mohammad R. Siahi-Shadbad & Farnaz Monajjemzadeh

  5. Department of Pharmaceutics, Tabriz University of Medical Sciences, Tabriz, Iran

    Hadi Valizadeh

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  1. Faranak Ghaderi
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Correspondence to Farnaz Monajjemzadeh.

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Ghaderi, F., Nemati, M., Siahi-Shadbad, M.R. et al. DSC kinetic study of the incompatibility of doxepin with dextrose. J Therm Anal Calorim 123, 2081–2090 (2016). https://doi.org/10.1007/s10973-015-4995-0

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  • DOI: https://doi.org/10.1007/s10973-015-4995-0

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