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Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility

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Abstract

Praziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly water-soluble drugs has become an important issue for analysis in pharmaceutical research. The use of dextran hydrogels is an advantageous strategy and the focus of extensive research. In this study, several hydrogels were developed from homologous polymer blends using 70 and 148 kDa dextrans in different proportions containing praziquantel, with the aim of evaluating the effects of polymeric release systems on the solubility of poorly water-soluble drugs such as praziquantel. Nine formulations were prepared, and the solubility of the drug incorporated was assessed. Three of the formations were selected to be characterized by DSC for the study in order to gain a better understanding of the thermal behavior of praziquantel incorporated into dextran hydrogels and the influence of polymers on the solubility of the drug, complemented by XRD and SEM techniques. According to the results, formation of crystallites of praziquantel occurred, probably due to the preparation procedures of the formulations, covering the surface of the polymer matrix and promoting a slight improvement in solubility. These data show that the use of hydrogels for the purposes of improving the solubility of poorly water-soluble drugs represents an effective strategy.

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Acknowledgements

We would like to thank the LMA-IQ/UNESP from Araraquara for the FEG-SEM facilities.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, UNESP – Univ Estadual Paulista, Araraquara, São Paulo, Brazil

    Flávio dos Santos Campos, Laís Zuzzi Ferrari, Adélia Emilia de Almeida & Maria Palmira Daflon Gremião

  2. Institute of Chemistry, UNESP – Univ Estadual Paulista, Araraquara, São Paulo, Brazil

    Douglas Lopes Cassimiro & Clóvis Augusto Ribeiro

  3. Department of Drugs and Pharmaceuticals, School of Pharmaceutical Sciences, São Paulo State University – UNESP, Rodovia Araraquara-Jaú, km 1, Araraquara, São Paulo, CEP 14801-902, Brazil

    Flávio dos Santos Campos

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  1. Flávio dos Santos Campos
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  2. Laís Zuzzi Ferrari
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  3. Douglas Lopes Cassimiro
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  4. Clóvis Augusto Ribeiro
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  5. Adélia Emilia de Almeida
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  6. Maria Palmira Daflon Gremião
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Correspondence to Flávio dos Santos Campos.

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Campos, F.d., Ferrari, L.Z., Cassimiro, D.L. et al. Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility. J Therm Anal Calorim 123, 2157–2164 (2016). https://doi.org/10.1007/s10973-015-4826-3

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  • DOI: https://doi.org/10.1007/s10973-015-4826-3

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