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Insight on thermal, spectral, magnetic and biological behaviour of new Ni(II), Cu(II) and Zn(II) complexes with a pentaazamacrocyclic ligand derived from nicotinamide

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Abstract

New species of type [MLCl2]·nH2O (M:Ni, n = 0; M:Cu, n = 1 and M:Zn, n = 0; L: 1,3,5,8,11-pentaazacyclotridecane-3-yl-(pyrid-3-yl)-methanone resulted by N,N’-bis(2-aminoethyl)ethane-1,2-diamine, nicotinamide and formaldehyde) were synthesised by one-pot condensation. Chemical analysis, ESI–MS, IR, 1H NMR, 13C NMR, UV–Vis–NIR, EPR spectroscopy as well as magnetic data at room temperature were used in order to characterise the compounds. The data provided by IR, ESI–MS and NMR spectra are consistent with the macrocycle formation. Electronic spectra indicate that both Ni(II) and Cu(II) adopt an octahedral stereochemistry data furthermore confirmed by magnetic moments and EPR spectrum at room temperature. The electrochemical behaviour of the compounds was investigated by cyclic voltammetry. Processes as water and chloride elimination as well as oxidative degradation of the macrocyclic ligand were observed by simultaneously TG–DTA measurements. The final residue as the most stable metallic oxide was identified by X-ray powder diffraction. The compound [CuLCl2]·H2O (2) exhibits fungicidal and anti-biofilm activity on Candida albicans strains. The complexes exhibit a low cytotoxicity on HEp 2 cells, except for Cu(II) species that induce the cellular cycle arrest in the G2/M phase.

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Acknowledgements

The PhD student F. Pătraşcu thanks to the Sectorial Operational Programme Human Resources Development (SOP HRD), financed from the European Social Fund and by the Romanian Government under the contract number SOP HRD/107/1.5/S/82514. Support of the EU (ERDF) and Romanian Government, that allowed the acquisition of the research infrastructure under POS-CCE O 2.2.1 project INFRANANOCHEM - Nr. 19/01.03.2009, is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania

    Rodica Olar, Florentina Pătraşcu, Dana Marinescu & Mihaela Badea

  2. Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor Str., 060601, Bucharest, Romania

    Mariana Carmen Chifiriuc, Luminiţa Măruţescu & Veronica Lazar

  3. Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania

    Emilia Elena Iorgulescu

  4. Stefan S Nicolau Institute of Virology, 285 Mihai Bravu Ave., Bucharest, Romania

    Coralia Bleotu

  5. “Ilie Murgulescu” Physical Chemistry Institute, Romanian Academy, 202 Splaiul Independenţei, 060021, Bucharest, Romania

    Nicolae Stanică

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  1. Rodica Olar
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  2. Florentina Pătraşcu
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  3. Mariana Carmen Chifiriuc
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  7. Veronica Lazar
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  8. Dana Marinescu
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  9. Nicolae Stanică
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  10. Mihaela Badea
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Correspondence to Mihaela Badea.

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Olar, R., Pătraşcu, F., Chifiriuc, M.C. et al. Insight on thermal, spectral, magnetic and biological behaviour of new Ni(II), Cu(II) and Zn(II) complexes with a pentaazamacrocyclic ligand derived from nicotinamide. J Therm Anal Calorim 118, 1159–1168 (2014). https://doi.org/10.1007/s10973-014-3864-6

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