Abstract
Herein, the present work comprises the synthesis of atorvastatin calcium (AVT) complexes with various transition metals. Ten kinds of complexes [Cr(AVT)2(Cl)(H2O)]·5H2O (1), [Mn(AVT)2(H2O)2] (2), [Fe(AVT)2(Cl)(H2O)]·9H2O (3), [Co(AVT)2(H2O)2]·8H2O (4), [Ni(AVT)2(H2O)2]·4H2O (5), [Cu(AVT)2(H2O)2] (6), [Zn(AVT)2]·2H2O (7), [Pt(AVT)2(Cl)2] (8), [Au(AVT)3] (9), and [Pd(AVT)(Cl)2] (10) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analyses. Results suggest that atorvastatin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against six different microorganisms, and the results were compared with the parent drug.
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This work was supported by grants from Princess Nora Bint Abdul Rahman University, Riyadh, Saudi Arabia under project Grants No. 22/32.
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Refat, M.S., Al-Saif, F.A. Synthesis, spectral, thermal, and antimicrobial studies of transition metal complexes of atorvastatin calcium as a lipid-lowering agent. J Therm Anal Calorim 120, 863–878 (2015). https://doi.org/10.1007/s10973-014-3784-5
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DOI: https://doi.org/10.1007/s10973-014-3784-5