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Palygorskite organophilic for dermopharmaceutical application

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Abstract

Due to the growing interest of the population in natural treatments, the clays represent a good alternative to the treatment of wounds. Its modification by organophilization happens when the same inorganic cations are exchanged for organic cations of the surfactant used in the process. Thus, the clay has the properties of its surface modified from being hydrophilic to hydrophobic, improving its functionality on the skin. In order to determine changes in surface palygorskite and to assess its healing action, this clay was organophilizated by two cationic surfactants: dimethyl benzyl ammonium chloride alkyl, and cetyl trimethyl ammonium chloride, and characterized by sieve analysis, property flow, test oil adsorption, and the techniques of X-ray fluorescence, X-ray diffraction, infrared Fourier transform, thermogravimetric analysis, scanning calorimetry—differential and histological of cutaneous wounds in rats. The results indicate that the attapulgite has good rheological properties, a high capacity of adsorption of oil, and the presence of clay minerals that reduce inflammation. The analysis by X-ray fluorescence is not observing any change in the crystal structure of palygorskite organophilizated but through infrared spectroscopy Fourier transform, verifying the interaction and incorporation of the clay ammonium salts, as well as thermoanalytical analysis also suggests that the organophilic process reduces the hydrophilic character of palygorskite. The histological analysis showed healing effect after topical application of natural and organophilizated clay in skin wounds in rats. These analyses favor a good prospect of its application in dermopharmaceuticals, because the use of palygorskite provides greater interaction with skin and heals wounds.

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Acknowledgements

The authors Coimbra Mining Ltda. for giving the clay for this study, the Hester Chemistry of Brazil Ltda for donating the quaternary ammonium salts, and UFPE and UFPI for the analyses, CNPQ and CAPES.

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Authors and Affiliations

  1. Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil

    Mirna Luciano de Gois da Silva, Amanda Campos Fortes, Rivelilson Mendes de Freitas & Cleide Maria da Silva Leite

  2. Postgraduate Program in Materials Science, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil

    Marília Evelyn Rodrigues Oliveira & Edson C. da Silva Filho

  3. Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco, 50740-520, Brazil

    Monica Felts de La Roca Soares & José Lamartine Soares-Sobrinho

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  1. Mirna Luciano de Gois da Silva
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  2. Amanda Campos Fortes
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  3. Marília Evelyn Rodrigues Oliveira
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Correspondence to Mirna Luciano de Gois da Silva.

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de Gois da Silva, M.L., Fortes, A.C., Oliveira, M.E.R. et al. Palygorskite organophilic for dermopharmaceutical application. J Therm Anal Calorim 115, 2287–2294 (2014). https://doi.org/10.1007/s10973-012-2891-4

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