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Carbohydrate recognition of symmetrical tripodal receptor type tris(2-aminoethyl)amine derivatives

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Abstract

Carbohydrate recognition of some bioactive symmetrical tripodal receptor type tris(2-aminoethyl)amine (TAEA) derivatives was investigated. In calorimetric experiments, the highest binding constant (Ka) of compound C (C35H49N5O4S) with methyl α-d-mannopyranoside was Ka = 858 M−1 with 1:1 stoichiometry. Formation of hydrogen bonds in binding between symmetrical tripodal receptor type compound C and sugars was suggested by the large negative values of ∆H° (=−34 to −511 kJ mol−1). In a comparison of each set of α- and β-anomers of some monosaccharides (methyl α/β-d-galactopyranoside, methyl α/β-d-glucopyranoside, and methyl α/β-l-fucopyranoside), compound C showed that the binding constant of β-anomer was larger than that of the corresponding α-anomer, indicating higher β-anomer selectivity. The calculated energy-minimized structure of the complex of compound C with guest methyl α-d-mannopyranoside is also presented. The experimental results obtained from this work indicated that symmetrical tripodal receptor type TAEA derivative C has a lectin-like carbohydrate recognition property.

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Acknowledgements

We thank Mr. Masato Ishimaru for his valuable technical assistance.

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Correspondence to Kunihiro Sumoto.

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Mibu, N., Aki, H., Ikeda, H. et al. Carbohydrate recognition of symmetrical tripodal receptor type tris(2-aminoethyl)amine derivatives. J Therm Anal Calorim 113, 1015–1018 (2013). https://doi.org/10.1007/s10973-012-2813-5

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  • DOI: https://doi.org/10.1007/s10973-012-2813-5

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