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Analysis of phase transition and dehydration processes of nevirapine

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Abstract

Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility.

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Acknowledgements

The authors wish to acknowledge the sponsorship of the FAPESP (Fundação de Amparo a Pesquisa) and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).

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Authors and Affiliations

  1. Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, 05508-900, Brazil

    George G. G. de Oliveira & Humberto G. Ferraz

  2. Department of Biotechnological Processes, School of Engineering Chemical, University of Campinas, Campinas, 13083-970, Brazil

    Patrícia Severino

  3. Department of Pharmaceutical Technology, Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, Office S.1, P-4200-150, Porto, Portugal

    Patrícia Severino & Eliana B. Souto

  4. Institute for Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás-os-Montes e Alto Douro (IBB-CGB/UTAD), 5001-801, Vila Real, Portugal

    Eliana B. Souto

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  1. George G. G. de Oliveira
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  2. Humberto G. Ferraz
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Correspondence to Eliana B. Souto.

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de Oliveira, G.G.G., Ferraz, H.G., Severino, P. et al. Analysis of phase transition and dehydration processes of nevirapine. J Therm Anal Calorim 108, 53–57 (2012). https://doi.org/10.1007/s10973-011-1424-x

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  • DOI: https://doi.org/10.1007/s10973-011-1424-x

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