Journal of Thermal Analysis and Calorimetry

, Volume 105, Issue 3, pp 1015–1021 | Cite as

Stability studies of capecitabine

  • M. Łaszcz
  • K. Trzcińska
  • K. Filip
  • A. Szyprowska
  • M. Mucha
  • P. Krzeczyński


Differential scanning calorimetry and thermogravimetry techniques were successfully used for stability studies of capecitabine. Decreasing values of melting temperature, heat of fusion, and peak purity calculated from the Van’t Hoff equation indicated the gradual decomposition of capecitabine stored at 40 °C in 75% of relative humidity. The increase in mass loss connected with the water sorption was observed simultaneously. High performance liquid chromatography proved the results of thermoanalytical studies. Infrared spectroscopy (IR) appeared to have the lower sensitivity for the decomposition products detection.


Thermal analysis IR HPLC Capecitabine 

Supplementary material

10973_2011_1351_MOESM1_ESM.doc (34 kb)
Supplementary material 1 (DOC 33 kb)


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2011

Authors and Affiliations

  • M. Łaszcz
    • 1
  • K. Trzcińska
    • 1
  • K. Filip
    • 1
  • A. Szyprowska
    • 1
  • M. Mucha
    • 1
  • P. Krzeczyński
    • 2
  1. 1.Department of R and D Analytical ChemistryPharmaceutical Research InstituteWarsawPoland
  2. 2.Department of ChemistryPharmaceutical Research InstituteWarsawPoland

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