Abstract
In this article, the quantitative determination of acetylsalicylic acid (ASA) contained in two of the most commercially available pharmaceutical formulations was performed using differential scanning calorimetry (DSC) after a thermoanalytical characterization and a preliminary test on compatibility of ASA with three of the most commonly considered excipients [cellulose (CE), starch (ST) and sodium saccharin (SS)]. Finally, the analytical results obtained were compared with those derived by titrimetry and two UV spectrophotometric methods: i.e. a ‘direct method’ and a method based on first-order derivative UV spectra.
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The authors warmly thank the Italian M.I.U.R. for its financial support.
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Campanella, L., Micieli, V., Tomassetti, M. et al. Quantitative determination of acetylsalicylic acid in commercial drugs using DSC. J Therm Anal Calorim 102, 249–259 (2010). https://doi.org/10.1007/s10973-010-0724-x
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DOI: https://doi.org/10.1007/s10973-010-0724-x