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Calorimetric studies of interactions of some peptides with electrolytes, urea and ethanol in water at 298.15 K

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The standard molar enthalpies of solution at infinite dilution \( \Updelta_{\text{sol}} H_{\text{m}}^{\infty } \) of glycylglycine, dl-alanyl-dl-alanine and glycylglycylglycine in aqueous solutions of potassium chloride and ethanol as well as of glycylglycine and glycylglycylglycine in the solutions containing urea and water have been determined by calorimetry at the temperature 298.15 K. Changes of solution enthalpy, expressed in a form so-called heterotactic interaction coefficients, \( h_{\text{xy}} \) were used for analysis of interactions occurring between the investigated solutes in water. The group contributions illustrating the interactions of KCl, urea and ethanol with selected functional groups in the peptide molecules, namely CH2, “pep,” and “ion” groups, were calculated and discussed.

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  1. Wszelaka-Rylik M, Zielenkiewicz W. Thermodynamic investigation of salting effect of ovalbumin in various salts solution. J Therm Anal Cal. 2007;87:85–9.

    Article  CAS  Google Scholar 

  2. Gorboletova GG, Kochergina LA. Thermochemical investigation of acid–base interactions in peptide solutions. J Therm Anal Cal. 2007;87:561–5.

    Article  CAS  Google Scholar 

  3. McLain SE, Soper AK, Watts A. Water structure around dipeptides in aqueous solutions. Eur Biophys. 2008;37:647–55.

    Article  CAS  Google Scholar 

  4. Smirnov VI, Badelin VG. Enthalpies of solution of l-l- and d-d-isomers of valine in aqueous alkanols at 298.15 K. J Solution Chem. 2008;37:1419–24.

    Article  CAS  Google Scholar 

  5. Mezhevoi IN, Badelin VG. Thermochemistry of glycyl-dl-α-alanine dissolution in water-alcohol solutions at 298.15 K. Russ J Gen Chem. 2008;78:1893–6.

    Article  CAS  Google Scholar 

  6. Nowicka B, Piekarski H. Calorimetric studies of interactions between simple peptides and electrolytes in water at 298.15 K. J Mol Liq. 2002;95:323–8.

    Article  CAS  Google Scholar 

  7. Piekarski H, Tkaczyk M. Effect of non-electrolyte properties on the enthalpic interaction coefficients of NaCl/NaI-non-electrolyte pairs in water. Dissolution enthalpies of NaCl and NaI in aqueous solutions of butan-2-one and 1,2-dimethoxyethane at 25°C. J Chem Soc Faraday Trans. 1991;87:3661–6.

    Article  CAS  Google Scholar 

  8. Nowicka B, Taniewska-Osińska S, Della Gatta G. Enthalpies of solution of N-acetylamino acid amides in aqueous solutions of electrolytes at the temperature 298.15 K. J Chem Thermodyn. 1997;29:1017–24.

    Article  CAS  Google Scholar 

  9. Piekarski H. Application of calorimetric methods to investigations of interactions in solutions. Pure Appl Chem. 1999;71:1275–83.

    Article  CAS  Google Scholar 

  10. Piekarski H. Calorimetry—An important tool in solution chemistry. Thermochim Acta. 2004;420:13–8.

    Article  CAS  Google Scholar 

  11. McMillan WG, Mayer JE. The statistical thermodynamics of multicomponent systems. J Chem Phys. 1945;13:276–305.

    Article  CAS  Google Scholar 

  12. Friedman HL, Krishnan CV. Studies of hydrogen bonding in aqueous alcohols: enthalpy measurements and model calculations. J. Solution Chem. 1973;2:119–40.

    Article  CAS  Google Scholar 

  13. Desnoyers JE, Perron G, Avedikian L, Morel J-P. Enthalpies of the urea–tert-butanol–water system at 25°C. J Solution Chem. 1976;5:631–44.

    Article  CAS  Google Scholar 

  14. Pałecz B. Enthalpies of solution of glycine in aqueous electrolyte solutions at 298.15 K. Thermochim Acta. 1991;180:199–202.

    Article  Google Scholar 

  15. Pałecz B, Taniewska-Osińska S. Enthalpies of solution of glycine in solutions of aqueous ureas at 298.15 K. Thermochim Acta. 1990;173:295–9.

    Article  Google Scholar 

  16. Pałecz B. The enthalpies of interaction of glycine with some alkan-1-ols in aqueous solutions at 298.15 K. Fluid Phase Equilibria. 1996;126:299–303.

    Article  Google Scholar 

  17. Wegrzyn TF, Hedwig GR. Excess enthalpies of aqueous solutions of (urea + one of four dipeptides). J Chem Thermodyn. 1984;16:843–50.

    Article  CAS  Google Scholar 

  18. Savage JJ, Wood RH. Enthalpy of dilution of aqueous mixtures of amides, sugars, urea, ethylene glycol, and pentaerythritol at 25°C: enthalpy of interaction of the hydrocarbon, amide, and hydroxyl functional groups in dilute aqueous solutions. J Solution Chem. 1976;5:733–50.

    Article  CAS  Google Scholar 

  19. Davis KG, Gallardo-Jimenez MA, Lilley TH. Enthalpies of interaction of sodium chloride and potassium chloride with some amides in water at 25°C. J Chem Soc Faraday Trans 1. 1989;85:2901–7.

    Google Scholar 

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Correspondence to Henryk Piekarski.

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Piekarski, H., Nowicka, B. Calorimetric studies of interactions of some peptides with electrolytes, urea and ethanol in water at 298.15 K. J Therm Anal Calorim 102, 31–36 (2010).

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