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Inhibitory study of two cephalosporins on E. coli by microcalorimetry

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Abstract

The microcalorimetric method has been used to study the effects of cefpiramide and ceftizoxime sodium on the E. coli growth. The results revealed that these two cephalosporins may alter the metabolic way of the E. coli. Moreover, the lethal doses of cefpiramide and ceftizoxime sodium are 2.000 and 0.2000 μg mL−1, respectively. Combining with the relationships between growth rate constant (k), the maximum power output (P m ), the time corresponding to the maximum power output (t m ) and cephalosporins concentration (C), one can draw the conclusion that the ceftizoxime sodium has a stronger inhibition effects on the growth of E. coli than that of cefpiramide and they both have the possibility to induce the drug fever.

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References

  1. Zhu JC, Li CH, Liu Y, Zhang ZH, Hou AX, Qu SS. A microcalorimetric study of the action of mercuric chloride on the metabolism of mitochondria isolated from Cyprinus carpio liver tissue. J Therm Anal Calorim. 2006;83:181–6.

    Article  CAS  Google Scholar 

  2. Wadsö I, Gomez F, Sjohölm I, Rocculi P. Effect of tissue wounding on the results from calorimetric measurements of vegetable respiration. Thermochim Acta. 2004;422:89–93.

    Article  Google Scholar 

  3. Yao J, Wang F, Tian L, Zhou Y, Chen HL, Chen K, et al. Studying the toxic effect of cadmium and hexavalent chromium on microbial activity of a soil and pure microbe. J Therm Anal Calorim. 2009;95:517–24.

    Article  CAS  Google Scholar 

  4. Zheng D, Liu Y, Zhang Y, Chen XJ, Shen YF. Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth. Environ Toxicol Pharmacol. 2006;22:121–7.

    Article  Google Scholar 

  5. Yan D, Han YM, Wei L, Xiao XH. Effect of berberine alkaloids on Bifidobacterium adolescentis growth by microcalorimetry. J Therm Anal Calorim. 2009;95:495–9.

    Article  CAS  Google Scholar 

  6. Trampuz A, Salzmann S, Antheaume J, Daniels AU. Microcalorimetry: a novel method for detection of microbial contamination in platelet products. Transfusion. 2007;47:1643–50.

    Article  Google Scholar 

  7. Yang LN, Xu F, Sun LX, Zhao ZB. A microcalorimetric study of the toxicity of two cobalt compounds on Escherichia coli DH5α growth. J Therm Anal Calorim. 2008;93:583–8.

    Article  CAS  Google Scholar 

  8. Ma J, Qi WT, Yang LN, Yu WT, Xie YB, Wang W, et al. Microcalorimetric study on the growth and metabolism of microencapsulated microbial cell culture. J Microbiol Meth. 2007;68:172–7.

    Article  CAS  Google Scholar 

  9. Liu Y, Deng FJ, Zhao RM, Shen XS, Wang CX, Qu SS. Microcalorimetric studies of the toxic action of La3+ in mitochondria isolated from Star-cross 288 chicken heart tissue cells. Chemosphere. 2000;40:851–4.

    Article  CAS  Google Scholar 

  10. Liu W, Chaspoul F, Berge Lefranc D, Decome L, Gallice P. Microcalorimetry as a tool for Cr(VI) toxicity evaluation of human dermal fibroblasts. J Therm Anal Calorim. 2007;89:21–4.

    Article  CAS  Google Scholar 

  11. Barry AL, Jones RN, Thornsberry C, Fuchs PC, Ayers LW, Gavan TL, et al. Cefpiramide: comparative in-vitro activity and β-lactamase stability. J Antimicrob Chemother. 1985;16:315–25.

    Article  CAS  Google Scholar 

  12. Nakagawa K, Koyama M, Matsui H, Ikeda C, Yano K, Nakatsuru N, et al. Pharmacokinetics of cefpiramide (SM-1652) in humans. Antimicrob Agents Chemother. 1984;25:221–5.

    CAS  Google Scholar 

  13. Bharathi C, Prasad CS, Bharathi DV, Shankar R, Rao VJ, Dandala R, et al. Structural identification and characterization of impurities in ceftizoxime sodium. J Pharm Biomed Anal. 2007;43:733–40.

    Article  CAS  Google Scholar 

  14. Roy K, Saha A, De K, Sengupta C. Evaluation of probucol as suppressor of ceftizoxime induced lipid peroxidation. Acta Pol Pharm. 2002;59:231–4.

    CAS  Google Scholar 

  15. Yang LN, Qiu SJ, Xu F, Sun LX, Zhao ZB, Liang JG, et al. Microcalorimetric investigation of the growth of the Escherichia coli DH5α in different antibiotics. J Therm Anal Calorim. 2007;89:875–9.

    Article  CAS  Google Scholar 

  16. Wadsö I. Isothermal microcalorimetry in applied biology. Thermochim Acta. 2002;394:305–11.

    Article  Google Scholar 

  17. Yang LN, Xu F, Sun LX, Tan ZC, Tan HD, Zhao ZB, et al. Study on interaction between antibiotics and Escherichia coli DH5α by microcalorimetric method. J Therm Anal Calorim. 2006;85:807–10.

    Article  CAS  Google Scholar 

  18. Xie CL, Tang HK, Song ZH, Qu SS, Liao YT, Liu HS. Microcalorimetric study of bacterial growth. Thermochim Acta. 1988;123:33–41.

    Article  Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge the National Natural Science Foundation of China for financial support to this work under Grant No. 50671098, 20473091 and 20573112.

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Authors and Affiliations

  1. Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, People’s Republic of China

    L. N. Yang, Li Xian Sun, J. Zhang & J. N. Zhao

  2. Department of Chemistry, Zunyi Normal College, Zunyi, 563002, People’s Republic of China

    L. N. Yang

  3. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, China

    Fen Xu

  4. Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, People’s Republic of China

    Z. B. Zhao

  5. Dalian Institute of Drug Detection, Dalian, 116021, People’s Republic of China

    C. G. Song & R. H. Wu

  6. Sony Corporation, Institute of Higher Education, Kanagawa, 2438501, Japan

    Riko Ozao

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  1. L. N. Yang
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  2. Li Xian Sun
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  4. J. Zhang
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  5. J. N. Zhao
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Correspondence to Li Xian Sun or Fen Xu.

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Yang, L.N., Sun, L.X., Xu, F. et al. Inhibitory study of two cephalosporins on E. coli by microcalorimetry. J Therm Anal Calorim 100, 589–592 (2010). https://doi.org/10.1007/s10973-009-0222-1

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  • DOI: https://doi.org/10.1007/s10973-009-0222-1

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