Skip to main content

Advertisement

SpringerLink
Log in

Thermodynamic properties of polymorphic forms of theophylline. Part I: DSC, TG, X-ray study

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

The physicochemical properties of theophylline hydrate and anhydrous polymorphic forms I and II were evaluated using crystallographic and calorimetric method. This study has been carried out with the following techniques: differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry. The X-ray patterns on powder for investigated compounds are presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Bettini R, Bertolini G, Frigo E, Rossi A, Casini I, Pasquali I, et al. Interaction of pharmaceutical hydrates with supercritical CO2. Solubility, solid-state and chemical modifications. J Therm Anal Calorim. 2004;77:625–38.

    Article  CAS  Google Scholar 

  2. Barbas R, Prohens R, Puigjaner C. A new polymorph of norfloxacin. Complete characterization and relative stability of its trimorphic system. J Therm Anal Calorim. 2007;89:687–92.

    Article  CAS  Google Scholar 

  3. Hilfiker R, Berghausen J, Blatter F, Burkhard A, De Paul SM, Freiermuth B, et al. Polymorphism integrated approach from high-throughput screening to crystallization optimization. J Therm Anal Calorim. 2003;73:429–40.

    Article  CAS  Google Scholar 

  4. Legendre B, Feutelais Y. Polymorphic and thermodynamic study of indomethacin. J Therm Anal Calorim. 2004;76:255–64.

    Article  CAS  Google Scholar 

  5. Griesser UJ, Szelagiewicz M, Hofmeier C, Pitt C, Cianferani S. Vapor pressure and heat of sublimation of crystal polymorphs. J Therm Anal Calorim. 1999;57:45–60.

    Article  CAS  Google Scholar 

  6. Grčman M, Vrečer F, Meden A. Some physico-chemical properties of doxazosin mesylate polymorphic forms and its amorphous state. J Therm Anal Calorim. 2002;68:373–87.

    Article  Google Scholar 

  7. Giron D. Applications of thermal analysis and coupled techniques in pharmaceutical industry. J Therm Anal Calorim. 2002;68:335–57.

    Article  CAS  Google Scholar 

  8. Giron D, Monnier S, Mutz M, Piechon P, Buser T, Stowasser F, et al. Comparison of quantitative methods for analysis of polyphasic pharmaceuticals. J Therm Anal Calorim. 2007;89:729–43.

    Article  CAS  Google Scholar 

  9. Drebushchak VA, Drebushchak TN, Chukanov NV, Boldyreva EV. Transitions among five polymorphs of chlorpropamide near the melting point. J Therm Anal Calorim. 2008;93:343–51.

    Article  CAS  Google Scholar 

  10. Perlovich GL, Volkova TV, Bauer-Brandl A. Polymorphism of paracetamol. Relative stability of the monoclinic and orthorhombic phase revisited by sublimation and solution calorimetry. J Therm Anal Calorim. 2007;89:767–74.

    Article  CAS  Google Scholar 

  11. Schmidt AC, Niederwanger V, Griesser UJ. Solid-state forms of prilocaine hydrochloride crystal polymorphism of local anaesthetic drugs, Part II. J Therm Anal Calorim. 2004;77:639–52.

    Article  CAS  Google Scholar 

  12. Caira MR, Bourne SA, Oliver CL. Thermal and structural characterization of two polymorphs of the bronchodilator tulobuterol. J Therm Anal Calorim. 2004;77:597–605.

    Article  CAS  Google Scholar 

  13. Caira MR, Foppoli A, Sangalli ME, Zem L, Giordano F. Thermal and structural properties of ambroxol polymorphs. J Therm Anal Calorim. 2004;77:653–62.

    Article  CAS  Google Scholar 

  14. Sun Ch, Zhou D, Grant D, Young VG. Theophylline monohydrate. Acta Cryst. 2002;58:368–70.

    Google Scholar 

  15. Bán M, Bombicz P, Madarász J. Thermal stability and structure of a new co-crystal of theophylline formed with phthalic acid TG/DTA-EGA-MS and TG-EGA-FTIR study. J Therm Anal Calorim. 2009;95:895–901.

    Google Scholar 

  16. Wesolowski M, Szynkaruk P. Thermal decomposition of methylxanthines interpretation of the results by PCA. J Therm Anal Calorim. 2008;93:739–46.

    Article  CAS  Google Scholar 

  17. Suzuki E, Shimomura K, Sekiguchi K. Thermochemical study of theophylline and its hydrate. Chem Pharm Bull. 1989;37:493–97.

    CAS  Google Scholar 

  18. Legendre B, Randzio SL. Transitiometric analysis of solid II/solid I transition in anhydrous theophylline. Int J Pharm. 2007;343:41–7.

    Article  CAS  Google Scholar 

  19. Legendre B, Baziard-Mouysset G, Anastassiadou M, Leger JM, Payard M. Polymorphic study of 2-(2-benzofuryl) Δ-2 imidazoline. J Therm Anal Calorim. 2001;66:659–73.

    Article  CAS  Google Scholar 

  20. Note of Editor: Melting points of the elements. Bull Alloy Phase Diagr. 1986;7:601–2.

    Google Scholar 

  21. Wang P. ICDD Grant-in-Aid. Brooklyn: Polytechnic Institute of New York; 1975.

    Google Scholar 

  22. Li Y. ICDD Grant-in-Aid. New York: Polytechnic Institute of Brooklyn; 1972.

    Google Scholar 

  23. Ebisuzaki Y, Boyle PD, Smith AS. Methylxanthines. I. Anhydrous theophylline. Acta Cryst. 1997;53:777–9.

    Article  Google Scholar 

  24. Sutor DJ. The structures of the pyrimidines and purines. VI. The crystal structure of theophylline. Acta Cryst. 1958;11:83–7.

    Article  CAS  Google Scholar 

  25. Otsuka M, Kaneniwa N, Kawakami K, Umezawa O. Effect of surface characteristics of theophylline anhydrate powder on hygroscopic stability. J Pharm Pharmacol. 1990;42:606–10.

    CAS  Google Scholar 

  26. Doser H. Die Schmelzpunkte des Pantokains, Bromurals und Theophyllins. Arch Pharm. 1943;53:251–6. (in German).

    Article  Google Scholar 

  27. Phadnis NV, Suryanarayanan R. Polymorphism in anhydrous theophylline-implications on the dissolution rate of theophylline tablets. J Pharm Sci. 1997;86:1256–63.

    Article  CAS  Google Scholar 

  28. Burger A, Ramberger RA. On the polymorphism of pharmaceuticals and other molecular crystals. I, Theory of thermodynamic rules. Mikrochim Acta. 1979;2:259–71.

    CAS  Google Scholar 

  29. Yu L. Inferring thermodynamic stability relationship of polymorphs from melting data. J Pharm Sci. 1995;84:966–74.

    Article  CAS  Google Scholar 

  30. Burger A, Ramberger R. Ramberger R. On the polymorphism of pharmaceuticals and other molecular crystals. II. Mikrochim Acta. 1979;256:273–316.

    Google Scholar 

Download references

Acknowledgements

The authors are grateful to Prof. S. L. Randzio for the preparation of investigated compounds. The author Piotr Szterner would like to thank the Centre of Excellence TALES (Thermodynamic Laboratory for Environmental Purposes) for the support.

Author information

Authors and Affiliations

  1. Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland

    Piotr Szterner

  2. Laboratoire de Chimie Physique Minérale et Bioinorganique EA 401, Faculté de Pharmacie, Université Paris XI Sud, 5 rue J-B Clément, 92296, Chatenay-Malabry Cedex, France

    Bernard Legendre & Mehrez Sghaier

Authors
  1. Piotr Szterner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bernard Legendre
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mehrez Sghaier
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Piotr Szterner.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Szterner, P., Legendre, B. & Sghaier, M. Thermodynamic properties of polymorphic forms of theophylline. Part I: DSC, TG, X-ray study. J Therm Anal Calorim 99, 325–335 (2010). https://doi.org/10.1007/s10973-009-0186-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10973-009-0186-1

Keywords

Search

Navigation