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A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

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Abstract

A combination of differential scanning calorimetry and hot-stage microscopy with image analysis has been used to investigate the polymorphism of sulfathiazole. The use of light intensity profiles obtained from the HSM images, as an alternative way to present results of the HSM analysis, was found to be useful in describing and verifying thermal events. The approach provides a unique insight into the polymorphic transformations and thermal behaviour exhibited by this compound. The results of the experiments show that sulfathiazole tends to crystallise as mixtures of polymorphs, even though the literature methods for producing pure polymorph were followed.

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Acknowledgements

The authors thank Dr. David Ross of the Department of Materials, Loughborough University for the use of the HSM system. Financial support provided by the Engineering and Physical Sciences Research Council (EPSRC), U.K., (grant EP/E022294/1) is gratefully acknowledged. One of the authors (MRAB) is grateful to the Malaysian Ministry of Higher Education and the International Islamic University Malaysia for a scholarship.

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Authors and Affiliations

  1. Department of Chemical Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK

    Mohd Rushdi Abu Bakar, Zoltan Kalman Nagy & Christopher David Rielly

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  1. Mohd Rushdi Abu Bakar
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  2. Zoltan Kalman Nagy
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  3. Christopher David Rielly
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Correspondence to Zoltan Kalman Nagy.

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Abu Bakar, M.R., Nagy, Z.K. & Rielly, C.D. A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism. J Therm Anal Calorim 99, 609–619 (2010). https://doi.org/10.1007/s10973-009-0001-z

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