Journal of Thermal Analysis and Calorimetry

, Volume 89, Issue 3, pp 875–879 | Cite as

Microcalorimetric investigation of the growth of the Escherichia coli DH5α in different antibiotics

  • L. N. Yang
  • S. J. Qiu
  • F. XuEmail author
  • L. X. Sun
  • Z. B. Zhao
  • J. G. Liang
  • C. G. Song


The effects of Amoxicillin Sodium and Cefuroxime Sodium on the growth of E. coli DH5α were investigated by microcalorimetry. The metabolic power-time curves of E. coli DH5α growth were determined by using a TAM air isothermal microcalorimeter at 37°C. By evaluation of the obtained parameters, such as growth rate constants (k), inhibitory ratio (I), the maximum heat power (P m) and the time of the maximum heat power (t m), one found that the inhibitory activity of Amoxicillin Sodium vs. E. coli DH5α is enhanced with the increasing of the Amoxicillin Sodium concentration, and the Cefuroxime Sodium has a stimulatory effect on the E. coli DH5α growth when the concentration is about 1 μg mL−1. The IC50 for the Amoxicillin Sodium and the Cefuroxime Sodium are 1.6 and 2.0 μg mL−1, respectively, it implicates that the E. coli DH5α is more sensitive to Amoxicillin Sodium than Cefuroxime Sodium.


Amoxicillin Sodium Cefuroxime Sodium E. coli DH5α inhibition microcalorimetry 


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Copyright information

© Springer Science+Business Media LLC 2007

Authors and Affiliations

  • L. N. Yang
    • 1
    • 2
  • S. J. Qiu
    • 1
    • 2
  • F. Xu
    • 1
    Email author
  • L. X. Sun
    • 1
  • Z. B. Zhao
    • 3
  • J. G. Liang
    • 4
  • C. G. Song
    • 5
  1. 1.Materials and Thermochemistry Laboratory, Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianP.R. China
  2. 2.Graduate School of the Chinese Academy of SciencesBeijingP.R. China
  3. 3.Division of Biotechnology, Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianP.R. China
  4. 4.Hunan Institute of Drug DetectionChangshaP.R. China
  5. 5.Dalian Institute of Drug DetectionDalianP.R. China

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