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Comparison of the fragility index of different eudragit polymers determined by activation enthalpies

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Abstract

The present study aimed to apply fragility index (m) of polymers in the determination of the optimal amount of plasticizer in polymer films. The fragility index of different Eudragit polymers (RS, RL, EPO) was assessed by differential scanning calorimerty (DSC), applying the Arrhenius connection (logq–1/T g). The fragility of Eudragit EPO films proved to be the highest, while in the case of RS and RL, the increase of the alkyl-chain length caused the increase of fragility. Studying the effect of plasticizer (triethyl citrate, TEC) on the m value of Eudragit RL and RS films, a near linear reduction of the fragility index could be observed between 5–30% TEC concentration, but above 30%, this value leveled out to constant.

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Authors and Affiliations

  1. Department of Pharmaceutics, Semmelweis University, Budapest, Hungary, 1092, Hőgyes E. Str. 7.

    Gabriella Csóka, A. Gelencsér, Eszter Pásztor & I. Klebovich

  2. University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary, 1092, Hőgyes E. Str. 7–9.

    Dorottya Kiss & Romána Zelkó

Authors
  1. Gabriella Csóka
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  2. A. Gelencsér
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  3. Dorottya Kiss
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  4. Eszter Pásztor
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  5. I. Klebovich
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  6. Romána Zelkó
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Corresponding author

Correspondence to Romána Zelkó.

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Csóka, G., Gelencsér, A., Kiss, D. et al. Comparison of the fragility index of different eudragit polymers determined by activation enthalpies. J Therm Anal Calorim 87, 469–473 (2007). https://doi.org/10.1007/s10973-006-7707-y

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  • DOI: https://doi.org/10.1007/s10973-006-7707-y

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