Abstract
Isothermal microcalorimetry was used to evaluate excipient compatibility of solid dosage form. Oxybutynin hydrochloride and cefaclor were used as model drugs for compatibility test with excipients. The calorimetric data for compatibility test were compared with those of HPLC data. Evaluation of compatibility between drug and excipient of solid dosage form might be possible to use isothermal microcalorimetry instead of conventional method. By using microcalorimetric method, the evaluation of the compatibility between drug and excipient could be successfully performed with a simple operation in a short time. The application of the isothermal microcalorimetry would be useful for the screening test of the drug compatibility with excipients.
Similar content being viewed by others
References
MA Phipps LA Mackin (2001) Pharm. Sci. Technol., Today 3 9 Occurrence Handle10.1016/S1461-5347(99)00227-8
S Gaisford G Buckton (2001) Thermochim. Acta 380 185 Occurrence Handle1:CAS:528:DC%2BD3MXos1ChsLk%3D Occurrence Handle10.1016/S0040-6031(01)00669-4
M Angberg C Nyström S Castensson (1988) Acta Pharm. Suec. 25 307 Occurrence Handle1:CAS:528:DyaL1MXhtVWltrs%3D
LD Hansen EA Lewis DJ Eatough RG Bergstron D DeGraft-Johnson (1989) Pharm. Res. 6 20 Occurrence Handle1:CAS:528:DyaL1MXht1WhtLg%3D Occurrence Handle10.1023/A:1015851100015
X Tan NSL Meltzer (1992) Pharm. Res. 9 1203 Occurrence Handle1:CAS:528:DyaK38Xlslyhtr0%3D Occurrence Handle10.1023/A:1015816225127
G Buckton AE Beezer (1991) Int. J. Pharm. 72 181 Occurrence Handle1:CAS:528:DyaK3MXkslylur8%3D Occurrence Handle10.1016/0378-5173(91)90106-X
S Torsten R Manfred K Jörg (1998) Int. J. Pharm. 171 227 Occurrence Handle10.1016/S0378-5173(98)00177-X
Y Yoshihashi Y Etsuo K Terada (2004) Netsu Sokutei 31 80 Occurrence Handle1:CAS:528:DC%2BD2cXjtlGgsrY%3D
EA Schmitt K Peck Y Sun JM Geoffroy (2001) Thermochim. Acta 380 175 Occurrence Handle1:CAS:528:DC%2BD3MXos1ChsLg%3D Occurrence Handle10.1016/S0040-6031(01)00668-2
F Fontani Ivo Setnikar (1974) Pharm. Ind. 36 802 Occurrence Handle1:CAS:528:DyaE2MXht12hsb0%3D
VF Samanidou EA Hapeshi IN Papadoyannis (2003) J. Chromatogr., B 788 147 Occurrence Handle1:CAS:528:DC%2BD3sXjtlymtb0%3D Occurrence Handle10.1016/S1570-0232(02)01040-1
G. W. Snedecor, W. G. Cochran, “Statistical Methods”, (Translated into Japanese), Iwanami Shoten, 1977, pp. 256–260
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Terada, K., Masuda, T., Yoshihashi, Y. et al. Application of microcalorimetry to the formulation study. J Therm Anal Calorim 85, 675–680 (2006). https://doi.org/10.1007/s10973-006-7654-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10973-006-7654-7