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Thermoanalytical study of organs of spontaneous hypertension rats

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Abstract

The thermal behavior of the kidney, heart and liver of spontaneous hypertension rats (SHR) were studied by thermogravimetry (TG) and differential thermal analysis (DTA). SHR are, by far, the most widely used rat model in the study of heart diseases in mammals, because they develop chronic hypertension, which leads to heart failure during their lives. TG curves showed two steps for all samples: at 800°C less residues remained for an SHR kidney (4.0±1.8%) than for an SHR heart (6.9±0.4) and liver samples (7.5±1.9%). It probably happened due to the presence of inorganic substances such as iron, calcium, magnesium, potassium and sodium. DTA curves depicted three endothermic events for kidney (70, 120 and 310°C), heart (85, 250 and 300°C) and liver samples (70, 250 and 310°C), indicating protein denaturation, as well as protein degradation and fat degradation, respectively. TG/DTG/DTA profiles of organs samples showed peculiarities that permit correlation between them. These methods might serve as a simple alternative to investigations over these vital organs.

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Authors and Affiliations

  1. Department of Organic Process, School of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, 21949-900

    Mothé C. G. & Carestiato T.

  2. Laboratory of Morphometry e Cardiovascular Morphology, State University of Rio de Janeiro, Rio de Janeiro, Brazil, 20551-030

    Silva S. P. S. & Aguila M. B.

Authors
  1. Mothé C. G.
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  2. Carestiato T.
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  3. Silva S. P. S.
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  4. Aguila M. B.
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Correspondence to Mothé C. G..

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Mothé, C.G., Carestiato, T., Silva, S.P.S. et al. Thermoanalytical study of organs of spontaneous hypertension rats. J Therm Anal Calorim 85, 61–63 (2006). https://doi.org/10.1007/s10973-005-7340-1

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  • DOI: https://doi.org/10.1007/s10973-005-7340-1

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