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Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate

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Abstract

A nanoscale multivalent platinum drug based on a poly(amidoamine) [PAMAM] dendrimer (generation 4.5, carboxylate surface) has been synthesized and fully characterized using a variety of spectroscopic, chromatographic and thermal methods. Treatment of the dendrimer with an aqueous solution containing an excess diaquo(cis-1,2-diaminocyclohexane)platinum(II) produces a conjugate containing approximately forty (diaminocyclohexane)platinum(II) moieties at the surface of the dendrimer. This material undergoes smooth two-stage thermal decomposition to provide residual platinum oxide reflecting the platinum loading in the drug.

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References

  1. RL Langer (1998) Nature 392 5 Occurrence Handle1:CAS:528:DyaK1cXjtVyls7g%3D

    CAS  Google Scholar 

  2. TA Allen PC Cullis (2004) Science 303 1818 Occurrence Handle1:CAS:528:DC%2BD2cXitFehu70%3D Occurrence Handle10.1126/science.1095833

    Article  CAS  Google Scholar 

  3. RL Langer (2000) Science 293 58 Occurrence Handle10.1126/science.1063273

    Article  Google Scholar 

  4. BA Howell EW Walles R Rashidianfar JR Glass BJ Hutchinson DA Johnson et al. (1988) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy Martinus Nijhoff Publishing Boston

    Google Scholar 

  5. BA Howell EW Walles R Rashidianfar (1988) Macromol. Chem., Macromol. Symp. 19 329 Occurrence Handle1:CAS:528:DyaL1cXmtlKrsL4%3D

    CAS  Google Scholar 

  6. BA Howell EW Walles (1988) Inorg. Chim. Acta 142 185 Occurrence Handle1:CAS:528:DyaL1cXhvFOhsL0%3D Occurrence Handle10.1016/S0020-1693(00)81555-8

    Article  CAS  Google Scholar 

  7. BA Howell R Rashidianfar JR Glass BJ Hutchinson DA Johnson (1988) Inorg. Chim. Acta 142 181 Occurrence Handle1:CAS:528:DyaL1cXitFGhsbs%3D Occurrence Handle10.1016/S0020-1693(00)81554-6

    Article  CAS  Google Scholar 

  8. RM Dyksterhouse BA Howell PJ Squattrito (2000) Acta Cryst. C56 64 Occurrence Handle1:CAS:528:DC%2BD3cXhsFGisb4%3D

    CAS  Google Scholar 

  9. JA Saltmarsh BA Howell PJ Squattrito (2000) Acta Cryst. C56 e335 Occurrence Handle1:CAS:528:DC%2BD3MXosFCisw%3D%3D

    CAS  Google Scholar 

  10. BA Howell RM Richards (1996) Polym. Mater. Sci. Eng. 74 274 Occurrence Handle1:CAS:528:DyaK28Xit1CiurY%3D

    CAS  Google Scholar 

  11. JC Roberts MK Bhalga RT Zera (1996) Biomed. Mater. Res. 30 53 Occurrence Handle1:CAS:528:DyaK28XisVyqsQ%3D%3D Occurrence Handle10.1002/(SICI)1097-4636(199601)30:1<53::AID-JBM8>3.0.CO;2-Q

    Article  CAS  Google Scholar 

  12. N Milak R Wiwattanapatapee R Klopsch K Lorenz H Frey JW Weener EW Meijer W Paulus G Carreno-Gomez N Malik R Duncan (2000) J. Cont. Rel. 65 133 Occurrence Handle10.1016/S0168-3659(99)00246-1

    Article  Google Scholar 

  13. L. Rakesh, J. Bridwell, D. Fan and B. A. Howell, manuscript in preparation.

  14. J Sambrook EF Fritsch T Maniatis et al. (1998) Molecular Cloning Cold Spring Harbor Press New York

    Google Scholar 

  15. S Deng J Locklin D Patton A Baba RC Advincula (2005) J. Am. Chem. Soc. 127 1744 Occurrence Handle1:CAS:528:DC%2BD2MXmslGqsA%3D%3D Occurrence Handle10.1021/ja046144l

    Article  CAS  Google Scholar 

  16. BA Howell LG Beholz BBS Sastry (1993) J. Thermal Anal. 40 395 Occurrence Handle1:CAS:528:DyaK2cXjtFCnsL0%3D

    CAS  Google Scholar 

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Authors and Affiliations

  1. Center for Applications in Polymer Science, Central Michigan University, Mt. Pleasant, USA, 48859-0001, MI

    Howell B. A., Fan D. & Rakesh Leela

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  1. Howell B. A.
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  2. Fan D.
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  3. Rakesh Leela
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Correspondence to Howell B. A..

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Howell, B.A., Fan, D. & Rakesh, L. Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate. J Therm Anal Calorim 85, 17–20 (2006). https://doi.org/10.1007/s10973-005-7333-0

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  • DOI: https://doi.org/10.1007/s10973-005-7333-0

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