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Synthesis and thermal study of the prodrug of oxamniquine

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Abstract

Oxamniquine polymeric prodrug with potential antischistosomal activity was prepared using dextran T-70 as a carrier, which was analysed by 1HNMR, 13C NMR and IR spectroscopy. The formation of the oxamniquine salt was confirmed by thermogravimetric analysis (TG) and differential scanning calorimetry (DSC) which showed a different thermal behaviour when compared to the physical mixture.

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Authors and Affiliations

  1. Programa de Pós-Graduaçăo em Ciências Farmacêuticas, Araraquara, Brazil, CEP 14802-902, SP , Unesp, Rod. Araraquara-Jaú, KM1

    Almeida A E

  2. Fundação Oswaldo Cruz, Centro de Pesquisa Gonçalo Moniz, Salvador, Brazil, CEP 40295001, BA

    Andrade Z A

  3. Departamento de Química Orgânica, Universidade Federal de Sâo Carlos-UFSCar, Brazil

    Ferreira A G

  4. Instituto de Química de Araraquara, Araraquara, Brazil, CEP 14800-900, , SP , Unesp, Av. Prof. Francisco Degni SN

    Crespi M S

  5. Lapdesf - Departamento de Fármacos e Medicamentos - Faculdade de Ciências Farmacêuticas, Araraquara, Brazil, CEP 14802-902, SP, Unesp Rod. Araraquara-Jaú, KM 1

    Chung M C

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  1. Almeida A E
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  2. Ferreira A G
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  3. Crespi M S
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  4. Andrade Z A
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  5. Chung M C
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Correspondence to Almeida A E.

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Almeida, A.E., Ferreira, A.G., Crespi, M.S. et al. Synthesis and thermal study of the prodrug of oxamniquine . J Therm Anal Calorim 83, 277–281 (2006). https://doi.org/10.1007/s10973-005-6875-5

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  • DOI: https://doi.org/10.1007/s10973-005-6875-5

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