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Fabrication of polycaprolactone-chitosan/curcumin polymer composite fibers and evaluation of their in vitro release kinetic behavior and antibacterial-antifungal activity

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Abstract

Microencapsulation is an attractive method in the production of controlled release and targeted delivery systems and is widely used to increase the bioavailability of antimicrobial molecules. Chitosan (CS) is commonly used as the wall material of microcapsules and demonstrates antibacterial and antifungal features. In this study, curcumin (CUR) and CS as bioactive substances were loaded in polycaprolactone (PCL) by microencapsulation method. The electrospinning method was used for the production of microencapsulated biomaterials as polymer composite fibers. SEM analysis of polymer composites was performed and the fiber size of PCL-CUR/CS composite fiber was measured as 248.71 ± 98 nm. The bioactive release kinetics correlation coefficient (R2) value and mathematical model of the polymer compounds were analyzed as PCL-CS/CUR; 0.98, Zero order, PCL-CUR; 0.93, Korsmeyer-Peppas and PCL-CS; 0.95 Higuchi, respectively. Antifungal activity experiments were performed on the obtained polymer composite fibers and the minimum inhibitory concentrations of PCL-CS, PCL-CUR, and PCL-CS/CUR composite fibers against Aspergillus niger were determined as >5000 ppm, 750 ppm, 2500 ppm, and 2500 ppm, respectively. The minimum inhibitory concentrations of PCL-CS, PCL-CUR, and PCL-CS/CUR against Penicillium digitatum were >5000 ppm, 250 ppm, 1666 ppm, and 1666 ppm, respectively. These results revealed that PCL/-CS/CUR polymer composite fibers may be used as both antifungal and antibacterial bioactive material in tissue engineering applications.

Graphical Abstract

Highlights

  • CUR and CS loaded into PCL via microencapsulation.

  • PCL-CS/CUR composite fibers were fabricated.

  • Composites had great antifungal-antibacterial activities with MIC against A. niger/P. digitatum.

  • CUR exhibits Zero-order, Korsmeyer–Peppas, and Higuchi release kinetics in fibers.

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Data availability

The author confirm that the data supporting the findings of this study are available within the article. Raw data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors would like to thank Fatih Sultan Mehmet Vakif University Technology Transfer Office and Biomedical Department Biomaterials BİORGİNE Laboratory for supporting this study.

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Authors and Affiliations

  1. Faculty of Engineering, Department of Biomedical Engineering, Fatih Sultan Mehmet Vakıf University, Istanbul, Turkey

    Fatih Ciftci

  2. Faculty of Chemical and Metallurgical Engineering, Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey

    Ali Can Özarslan

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  1. Fatih Ciftci
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  2. Ali Can Özarslan
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FÇ: conceptualization, methodology, investigation, formal analysis, writing—original draft, visualization. ACÖ: conceptualization, methodology, formal analysis, writing—review and editing.

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Correspondence to Fatih Ciftci.

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Ciftci, F., Özarslan, A.C. Fabrication of polycaprolactone-chitosan/curcumin polymer composite fibers and evaluation of their in vitro release kinetic behavior and antibacterial-antifungal activity. J Sol-Gel Sci Technol 109, 192–203 (2024). https://doi.org/10.1007/s10971-023-06264-x

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