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In vitro and in silico investigations by two new pH sensitive magnetic ferrate nanocarriers for delivery of 5-fluorouracil and chlorambucil

  • Original Paper: Nano-structured materials (particles, fibers, colloids, composites, etc.)
  • Published:
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Abstract

In the preset study, potassium-calcium ferrate (KCaFeO4) and sodium-calcium ferrate (NaCaFeO4) nanoparticles were synthesized by thermal treatment method and the KCaFeO4@GO and NaCaFeO4@SiO2 nanocomposites were obtained by chemical processes. Different characterization techniques, such as X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM) coupled with energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and Fourier transform infrared (FT–IR) spectroscopy were investigated to confirm the degree of crystallinity, microstructure, elemental analysis, morphology, and phase composition respectively. The prepared ferrate nanocomposites was used as a drug delivery carrier for 5-fluorouracil (5-FU) and chlorambucil (CLB) drugs. These drugs were loaded in to mentioned ferrate nanocomposites to compare effectiveness and cytotoxicity against the cancer and healthy cells. The cytotoxicity and anticancer activity of the drug against the MCF-7 cells were estimated by MTT assay. Results showed prepared drug loaded ferrate nanocomposites clearly decrease cell toxicity of loaded chemotherapeutic agents and these are two samples based 5-FU and CLB drugs are economically efficient drugs for curing breast cancer.

Graphical abstract

Highlights

  • A simple thermal treatment method was used to make two nanocomposites of KCaFeO4@GO and NaCaFeO4@SiO2.

  • 5-FU and CLB drugs were loaded in to mentioned nanocarriers to compare effectiveness and cytotoxicity.

  • The degree of crystallinity, microstructure, morphology, and phase composition of samples were examined by different techniques.

  • The cytotoxicity and anticancer activity of the drug against the MCF-7 cells were estimated by MTT assay.

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Acknowledgements

This work was supported by the Ministry of science research and technology of Iran under the FRGS grant, Malayer University of Iran.

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Authors and Affiliations

  1. Department of Physics, Faculty of Science, Malayer University, Malayer, Iran

    Azam Hashemi, Mahmoud Naseri & Mahshid Chireh

  2. Department of Biology, Faculty of Science, Malayer University, Malayer, Iran

    Maryam Rahimi

  3. Faculty of Physics, Semnan University, Semnan, 35195-363, Iran

    Mohammad Mahdi Shahidi

  4. Department of Chemistry, Arak Branch, Islamic Azad University, Arak, Iran

    Nima Shirmohammadi

  5. Growth Center of Technology unit, Qom University of Medical Sciences, Qom, Iran

    Arefeh Khodaee

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  1. Azam Hashemi
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Correspondence to Mahmoud Naseri.

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Hashemi, A., Naseri, M., Rahimi, M. et al. In vitro and in silico investigations by two new pH sensitive magnetic ferrate nanocarriers for delivery of 5-fluorouracil and chlorambucil. J Sol-Gel Sci Technol 106, 54–66 (2023). https://doi.org/10.1007/s10971-022-05996-6

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