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Porous silica coated gold nanocages for chemo-photothermal combined therapy

Journal of Sol-Gel Science and Technology volume 100, pages 562–570 (2021)Cite this article

Abstract

The combination therapy that combines drug delivery with other treatments (e.g., photothermal therapy) has great advantages in treating tumors. Here, we prepared a promising versatile platform based on gold nanocages (Au NCs) poly (N-isopropylacrylamide) (PNIPAM) entrapped porous silica core−shell nanostructure (Au@SiO2-PNIPAM). This system not only served as a container for therapeutic drugs, but also had high photothermal conversion efficiency. The thermosensitive PNIPAM wrapping around porous silica acted as a gatekeeper to encapsulate the drug molecules within the channels of Au@SiO2-PNIPAM carrier. Under the light irradiation, Au NCs could absorb near-infrared (NIR) light and convert it into heat, which would promote the swelling of PNIPAM layer for releasing drug. The Au@SiO2-PNIPAM displays pH/light-responsive drug release and excellent photothermal-chemical combined therapeutic effect.

Porous silica coated Au nanocages (Au NCs) (Au@SiO2) carriers were designed and prepared for drug release.

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Authors and Affiliations

  1. National & Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials, Henan University, Kaifeng, 475004, China

    Jun Hou, Yunyun Chen, Yanbao Zhao, Xueyan Zou & Lei Sun

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  1. Jun Hou
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  2. Yunyun Chen
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  3. Yanbao Zhao
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  4. Xueyan Zou
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  5. Lei Sun
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Correspondence to Yanbao Zhao.

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Hou, J., Chen, Y., Zhao, Y. et al. Porous silica coated gold nanocages for chemo-photothermal combined therapy. J Sol-Gel Sci Technol 100, 562–570 (2021). https://doi.org/10.1007/s10971-021-05672-1

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  • DOI: https://doi.org/10.1007/s10971-021-05672-1

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