The combination therapy that combines drug delivery with other treatments (e.g., photothermal therapy) has great advantages in treating tumors. Here, we prepared a promising versatile platform based on gold nanocages (Au NCs) poly (N-isopropylacrylamide) (PNIPAM) entrapped porous silica core−shell nanostructure (Au@SiO2-PNIPAM). This system not only served as a container for therapeutic drugs, but also had high photothermal conversion efficiency. The thermosensitive PNIPAM wrapping around porous silica acted as a gatekeeper to encapsulate the drug molecules within the channels of Au@SiO2-PNIPAM carrier. Under the light irradiation, Au NCs could absorb near-infrared (NIR) light and convert it into heat, which would promote the swelling of PNIPAM layer for releasing drug. The Au@SiO2-PNIPAM displays pH/light-responsive drug release and excellent photothermal-chemical combined therapeutic effect.
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Lee JE, Lee N, Kim T, Kim J, Hyeon T (2011) Multifunctional mesoporous silica nanocomposite nanoparticles for theranostic applications. Acc Chem Res 44:893–902
Yang YJ, Tao X, Hou Q, Ma Y, Chen XL, Chen JF (2010) Mesoporous silica nanotubes coated with multilayered polyelectrolytes for pH-controlled drug release. Acta Biomater 6:3092–3100
Frank C, Rachel AC, Helmuth M (1998) Nanoengineering of inorganic and hybrid hollow spheres by colloidal tlating. Science 282:1111–1114
Zhang Y, Chan HF, Leong KW (2013) Advanced materials and processing for drug delivery: the past and the future. Adv Drug Deliv Rev 65:104–120
Xu PS, Li SY, Li Q, Van Kirk EA, Ren J, Murdoch WJ, Zhang ZJ, Radosz M, Shen YQ (2008) Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery. Angew Chem Int Ed 47:1260–1264
Aznar E, Oroval M, Pascual L, Murguía JR, Martínez-Máñez R, Sancenón F (2016) Gated Materials for on-command release of guest molecules. Chem Rev 116:561–718
Chen ZY, Wan LH, Yuan Y, Kuang Y, Xu XY, Liao T, Liu J, Xu ZQ, Jiang BB, Li C (2020) pH/GSH-dual-sensitive hollow mesoporous silica nanoparticle-based drug delivery system for targeted cancer therapy. ACS Biomater 6:3375–3387
Bai L, Yi W, Wang Y, Tian Y, Zhou B, Yi T, Zhang P, Cheng X, Si J, Hou X, Hou J (2021) A PdMo bimetallene with precise wavelength adjustment and catalysis for synergistic photothermal ablation and hydrogen therapy of cancer at different depths. J Mater Chem B 9:6441–6459
Liu JW, Liu Y (2003) A colorimetric lead biosensor using DNAzyme-directed assembly of gold nanoparticles. J Am Chem Soc 125:6642–6643
Abrams MJ, Murrer BA (1993) Metal compounds in therapy and diagnosis. Science 261(5122):725–730
Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A, Lotan R, Richards-Kortum R (2003) Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. Cancer Res 63:1999–2004
Liao HW, Nehl CL, Hafner JH (2006) Biomedical applications of plasmon resonant metal nanoparticles. Nanomedicine 1:201–208
Chen JY, Wang DL, Xi JF, Au L, Siekkinen A, Warsen A, Li ZY, Zhang H, Xia YN, Li XD (2007) Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. Nano Lett 7:1318–1322
Koutecky J, Pacchioni G, Jeung GH (1985) Comparative study of tetramers built from I a,II a, III a, and IV a atoms. Surf Sci 156:650–669
Dipankar S, Halas NJ (1997) General vector basis function solution of Maxwell’s equations. Am Phys Soc 56:1102–1112
Sun YG, Xia YN (2002) Increased sensitivity of surface plasmon resonance of gold nanoshells compared to that of gold solid colloids in response to environmental changes. Anal Chem 74:5297–5305
Montoto AH, Montes R, Samadi A, Gorbe M, Terres JM, Cao-Milan R, Aznar E, Ibanez J, Masot R, Marcos MD, Orzaez M, Sancenon F, Oddershede LB, Martinez-Manez R (2018) Gold nanostars coated with mesoporous silica are effective and nontoxic photothermal agents capable of gate keeping and laser-induced drug release. ACS Appl Mater Interfaces 10:27644–27656
Skrabalak SE, Chen J, Au L, Lu X, Li X, Xia YN (2007) Gold nanocages for biomedical applications. Adv Mater 19:3177–3184
Au L, Chen JY, Wang LV, Xia YN (2010) Gold Nanocages for cancer imaging and therapy. Cancer Nanotechnol 1:83–99
Yang JP, Shen DK, Zhou L, Li W, Li XM, Yao C, Wang R, El-Toni AM, Zhang F, Zhao DY (2013) Spatially confined fabrication of core-shell gold nanocages@mesoporous silica for near-infrared controlled photothermal drug release. Chem Mater 25:3030–3037
Shi P, Liu Z, Dong K, Ju EG, Ren JS, Du YD, Li ZQ, Qu XG (2014) A smart “sense-act-treat” system: combining a ratiometric pH sensor with a near infrared therapeutic gold nanocage. Adv Mater 26:6635–6641
Peng SW, He YY, Er M, Sheng YQ, Gu YQ, Chen HY (2017) Biocompatible CuS-based nanoplatforms for efficient photothermal therapy and chemotherapy in vivo. Biomater Sci 5:475–484
Yin NQ, Wu P, Yang TH, Wang M (2017) Preparation and study of a mesoporous silica-coated Fe3O4 photothermal nanoprobe. RSC Adv 7:9123–9129
Zhao W, Li AH, Chen C, Quan FY, Sun L, Zhang AT, Zheng YW, Liu JQ (2017) Teansferrin-decorated, MoS2-capped hollow mesoporous silica nanospheres as a self-guided chemo-photothermal nanoplatform for controlled drug release and thermotherapy. J Mater Chem B 5:7403–7414
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Hou, J., Chen, Y., Zhao, Y. et al. Porous silica coated gold nanocages for chemo-photothermal combined therapy. J Sol-Gel Sci Technol 100, 562–570 (2021). https://doi.org/10.1007/s10971-021-05672-1