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Tri-responsive porous silica carrier with gold nanoparticles for chemophotothermal combination therapy

  • Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
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A multifunctional nanoplatform (pSiO2–Au/HA) combining porous silica (pSiO2) carriers and gold nanoparticles (Au NPs) was synthesized for chemophotothermal synergistic therapy. The pSiO2 carrier has the diameter size of 70 nm and high specific surface area (510.8 m2·g−1). Au NPs as photothermal agents and gatekeepers were linked to pSiO2 carriers by Au–S bonds for redox-responsive drug release and photothermal effect. Hyaluronic acid (HA) molecules were conjugated by the amide bonds on the surface of porous silica (pSiO2) to seal the drug-loaded pores and endow it pH-and enzyme-responsive property. The results demonstrated that pSiO2–Au/HA carriers displayed good pH/redox/enzyme-responsive release behavior and photothermal effect, which may be a good promising targeted delivery systems for chemophotothermal therapy.


  • Porous silica (pSiO2) carriers were successfully prepared for drug release.

  • Hyaluronic acid (HA) and gold nanoparticles (Au NPs) are used to seal the loaded drug.

  • pSiO2-Au/HA carriers display pH/redox/enzyme-responsive release behavior.

  • pSiO2-Au/HA carriers exhibit good aqueous and photostability.

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  1. Mahmoudi M, Sant S, Wang B, Laurent S, Sen T (2011) Adv Drug Deliv Rev 63:24–46

    Article  CAS  Google Scholar 

  2. Zhang Z, Wang J, Chen C (2013) Adv Mater 25:3869–3880

    Article  CAS  Google Scholar 

  3. Zhang X, Wang Y, Zhao Y, Sun L (2017) Mater Sci Eng C 77:19–26

    Article  CAS  Google Scholar 

  4. Jiang W, Mo F, Jin X, Chen L, Xu LJ, Guo L, Fu F (2017) Adv Mater Interfaces 4:1700425

    Article  Google Scholar 

  5. He H, Zhu R, Sun W, Cai K, Chen Y, Yin L (2018) Nanoscale 10:2856–2865

    Article  CAS  Google Scholar 

  6. Ranji-Burachaloo H, Reyhani A, Gurr PA, Dunstan DE, Qiao GG (2019) Nanoscale 11:5705–5716

    Article  CAS  Google Scholar 

  7. Markeb AA, El-Maali NA, Sayed DM, Osama A, Abdel-Malek MAY, Zaki AH, Elwanis MEA, Driscoll JJ (2016) Int J Breast Cancer 2016:1–8

    Article  Google Scholar 

  8. Croissant JG, Fatieiev Y, Almalik A, Khashab NM (2018) Adv Healthc Mater 7:1700831

    Article  Google Scholar 

  9. Cao N, Zhao Y, Sang B, Wang Z, Cao L, Sun L, Zou X (2016) Mater Sci Eng C 69:330–336

    Article  CAS  Google Scholar 

  10. Cao N, Xie X, Zhang Y, Zhao Y, Cao L, Sun L (2016) J Ind Eng Chem 34:9–13

    Article  CAS  Google Scholar 

  11. Zhang Q, Guo J, Zhang X, Zhao Y, Cao L, Sun L (2018) Sens Actuators B 276:370–377

    Article  CAS  Google Scholar 

  12. Montoto AH, Montes R, Samadi A, Gorbe M, Terrés JM, Cao-Milán R, Aznar E, Ibañez J, Masot R, Marcos MD, Orzáez M, Sancenón F, Oddershede LB, Martínez-Máñez R (2018) ACS Appl Mater Interfaces 10:27644–27656

    Article  Google Scholar 

  13. Zhang Z, Wang J, Nie X, Wen T, Ji Y, Wu X, Zhao Y, Chen C (2014) J Am Chem Soc 136:7317–7326

    Article  CAS  Google Scholar 

  14. Moreira AF, Rodrigues CF, Reis CA, Costa EC, Correia IJ (2018) Microporous Mesoporous Mater 270:168–179

    Article  CAS  Google Scholar 

  15. Hu Y, Liu Y, Xie X, Bao W, Hao J (2018) J Colloid Interface Sci 529:547–555

    Article  CAS  Google Scholar 

  16. Villaverde G, Gómez-Graña S, Guisasola E, García I, Hanske C, Liz-Marzán LM, Baeza A, Vallet-Regí M (2018) Part Part Syst Charact 35:1800148

    Article  Google Scholar 

  17. Poudel BK, Soe ZC, Ruttala HB, Gupta B, Ramasamy T, Thapa RK, Gautam M, Ou W, Nguyen HT, Jeong J-H, Jin SG, Choi H-G, Yong CS, Kim JO (2018) Int J Pharm 548:92–103

    Article  CAS  Google Scholar 

  18. Huang X, Tang S, Mu X, Dai Y, Chen G, Zhou Z, Ruan F, Yang Z, Zheng N (2010) Nat Nanotech 6:28–32

    Article  Google Scholar 

  19. Yang Y, Lin Y, Di D, Zhang X, Wang D, Zhao Q, Wang S (2017) J Colloid Interface Sci 508:323–331

    Article  CAS  Google Scholar 

  20. Mattheolabakis G, Milane L, Singh A, Amiji MM (2015) J Drug Target 23:605–618

    Article  CAS  Google Scholar 

  21. Du X, Li X, Huang H, He J, Zhang X (2015) Nanoscale 7:6173–6184

    Article  CAS  Google Scholar 

  22. Tournebize J, Boudier A, Sapin-Minet A, Maincent P, Leroy P, Schneider R (2012) ACS Appl Mater Interfaces 4:5790–5799

    Article  CAS  Google Scholar 

  23. Qiu L, Zhao Y, Cao N, Cao L, Sun L, Zou X (2016) Sens Actuators B 234:21–26

    Article  CAS  Google Scholar 

  24. Zhang X, Zhao Y, Cao L, Sun L (2018) Sens Actuators B 257:105–115

    Article  CAS  Google Scholar 

  25. Zhou H, Xu H, Li X, Lv Y, Ma T, Guo S, Huang Z, Wang X, Xu P (2017) Mater Sci Eng C 81:261–270

    Article  CAS  Google Scholar 

  26. Rahoui N, Jiang B, Hegazy M, Taloub N, Wang Y, Yu M, Huang YD (2018) Colloids Surf B 171:176–185

    Article  CAS  Google Scholar 

  27. Guo Z, Zheng K, Tan Z, Liu Y, Zhao Z, Zhu G, Ma K, Cui C, Wang L, Kang T (2018) J Mater Chem B 6:7750–7759

    Article  CAS  Google Scholar 

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Financial support of this work from National Natural Science Foundation of China (21271062) is gratefully acknowledged.

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Correspondence to Yanbao Zhao.

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Chen, Y., Zhao, Y., Sun, L. et al. Tri-responsive porous silica carrier with gold nanoparticles for chemophotothermal combination therapy. J Sol-Gel Sci Technol 93, 332–340 (2020).

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