The evaluation of the antifungal activity of Mg(OH)2 and Ca(OH)2 nanoparticles (NPs), synthesized by sol–gel method and their mixtures at different concentrations, is reported. The antifungal activity of the hydroxide NPs was studied using Aspergillus niger and Penicillium oxalicum isolated from stone surfaces. These model organisms were selected due to their ability to grow on outdoor and indoor climates and their significant impact on human health. Moreover, the antifungal activity of Mg(OH)2 and Ca(OH)2 NPs dispersed in positively charged polymeric matrices based on partially quaternized poly(2-(dimethylamino ethyl) methacrylate) (pDMAEMA) was studied. With respect to the morphology, particle size, and textural properties of the NPs, the mixtures of Mg–Ca hydroxides revealed a uniform and smaller particle size, along with a greater surface area, as compared to pristine Ca(OH)2 NPs. However, the Ca(OH)2 and a mixture of Mg(OH)2 and Ca(OH)2 (10:90 weight ratio) NPs, showed an enhanced growth inhibition of A. niger and P. oxalicum, suggesting that the effect of particle size on the antifungal activity would not be a preponderating factor. In addition, improved antifungal properties against A. niger and P. oxalicum were detected in composite coatings based on hydroxide NPs dispersed in quaternized p(DMAEMA-co-METAI). The use of these systems might provide promising composite materials with potential antifungal properties for various applications.
Pure Mg(OH)2, Ca(OH)2, and mixtures of both NPs were successfully synthesized by sol–gel method.
The mixtures based on Mg–Ca hydroxides showed a uniform and smaller particle size, along with a greater surface area.
The effect of particle size on the antifungal activity would not be a preponderating factor.
The Ca(OH)2 and Mg(OH)2:Ca(OH)2 (10:90 wt%) NPs had an enhanced antifungal efficiency.
The use of Mg(OH)2 and Ca(OH)2 NPs in p(DMAEMA-co-METAI) composites improved the antifungal efficacy of polymeric matrices.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
Tax calculation will be finalised during checkout.
Giles C, Lamont-Friedrich SJ, Michl TD, Griesser HJ, Coad BR (2018) Biotechnol Adv 36:264–280
Cámara B, Souza-Egipsy V, Ascaso C, Artieda O, De los Ríos A, Wierzchos J (2016) Chem Geol 443:22–31
Garrido-Benavent I, Pérez-Ortega S, De los Ríos A (2017) Mol Phylogenet Evol 107:117–131
Burforf EP, Fomina M, Gadd GM (2003) Mineral Mag 67:1127–1155
Gadd GM (2017) Nat Microbiol 2:16275
Gueidan C, Villaseñor CR, De Hoog GS, Gorbushina AA, Untereiner WA, Lutzoni F (2008) Stud Mycol 61:111–119
Egbuta MA, Mwanza M, Oluranti Babalola O (2017) Int J Environ Res Public Health 14:719
Sierra-Fernandez A, De la Rosa-García SC, Gómez-Villalba LS, Gómez-Cornelio S, Rabanal ME, Fort R, Quintana P (2017) ACS Appl Mater Interfaces 9:24873–24886
Wang L, Chen H, Shao L (2017) Int J Nanomed 12:1227–1249
Farrokhi M, Yang JK, Lee SM, Shirzad-Siboni M (2013) J Environ Health Sci Eng 2:11–23
Ruffolo SA, La Russa MF, Malagodi M, Oliviero Rossi C, Palermo AM, Crisci GM (2010) Appl Phys A: Mater 100:829–834
Gómez-Ortíz N, De la Rosa-García S, González-Gómez W, Soria-Castro M, Quintana P, Oskam G, Ortega-Morales B (2013) ACS Appl Mater Interfaces 5:1556–1565
Božanić D, Dimitrijević-Branković S, Bibić N, Luyt AS, Djoković V (2011) Carbohydr Polym 83:883–890
Bognadović U, Lazić V, Vodnik V, Budimir M, Marković Z, Dimitrijević S (2014) Mater Lett 128:75–78
Elhusseiny AF, Hassan HH (2013) Spectrochim Acta A Mol Biomol Spectrosc 103:232–245
Raghunath A, Perumal (2017) Int J Antimicrob Agents 49:137–152
Khatir NM, Abdul-Malek Z, Zak AK, Akbari A, Sabbagh F (2016) J Sol-Gel Sci Technol 78:91–98
Chandra Ray P, Yu H, Fu PP (2009) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:1–35
Kabir E, Kumar V, K-H Kim, ACK Yip (2018) J Environ Manage 225: 261–271
Booster JL, Van Sandwijk A, Reuter MA (2003) Miner Eng 16:273–281
Sierra-Fernandez A, Gomez-Villalba LS, Rabanal ME, Fort R (2017) Mater Constr 67:325
Poggi G, Giorgi R, Toccafondi N, Katzur V, Baglioni P (2010) Langmuir 26:19084–19090
Al-Hazmi F, Umar A, Dar GN, Al-Ghamdi AA, Al-Sayari SA, Al-Hajry A, Kim SH, Al-Tuwirqi RM, Alnowaiserb F, El-Tantawy F (2012) J Alloy Compd 519:4–8
Janning C, Willbold E, Vogt C, Nellesen J, Meyer-Lindenberg A, Windhagen H, Thorey F, Witte F (2010) Acta Biomater 6:1861–1868
Qiu L, Xie R, Ding P, Qu B (2003) Compos Struct 62:391–395
Natali I, Tempesti P, Carretti E, Potenza M, Sansoni S, Baglioni P, Dei L (2014) Langmuir 30:660–668
Zhu G, Schwendeman SP (2000) Pharm Res 17:351–357
Pan X, Wang Y, Chen Z, Pan D, Cheng Y, Liu Z, Lin Z, Xiong G (2013) ACS Appl Mater Interfaces 5:1137–1142
Samanta A, Podder S, Ghosh CK, Bhattacharya M, Ghosh J, Mallik AK, Mukhopadhyay AK (2017) J Mech Behav Biomed Mater 72:110–128
Halbus AF, Horozov TS, Paunov N (2017) Adv Colloid Interface Sci 249:134–148
Santos MRE, Fonseca AC, Mendonça PV, Branco R, Serra AC, Morais PV, Coelho JFJ (2016) Materials 9:599
Tang L, Gu W, Yi W, Bitter JL, Hong JY, Fairbrother DH, Loon Chen K (2013) J Membr Sci Technol 446:201–211
Wu T, Luo X, Li W, Song R, Li J, Li Y, Li B, Liu S (2016) Food Chem 197:250–256
Liu T, Ding E, Xue F (2017) Int J Biol Macromol 103:1107–1112
Yamada K, Takagi C, Hirata M (2007) J Appl Polym Sci 104:3301–3308
Romano CE, Gallo EA (2001) Ink Jet Print Method 6:202–224. US Patent
Hinton TM, Challagulla A, Stewart CR, Guerrero- Sanchez C, Grusche FA, Shi S, Bean AG, Monaghan P, Gunatillake PA, Thang SH, Tizard ML (2014) Nanomedicine 9:1141–1154
Hinton TM, Guerrero-Sanchez C, Graham JE, Le T, Muir BW, Shi S, Tizard MLV, Gunatillake PA, McLean KM, San H, Thang SH (2012) Biomaterials 33:7631–7642
Ravikumar T, Murata H, Koepsel RR, Russell A (2006) Biomacromolecules 7:2762–2769
Rawlinson L-AB, Ryan SM, Mantovani G, Syrett JA, Haddleton DM, Brayden DJ (2010) Biomacromolecules 11:443–453
Yandi W, Mieszkin S, Callow ME, Callow JA, Finlay JA, Liedberg B, Edert T (2017) Biofouling 33:169–183
Chen Y, Wilbon PA, Chen YP, Zhou J, Nagarkatti M, Wang C, Chu F, Decho AW, Tang C (2012) RSC Adv 2:10275–10282
Yañez-Macias R, Alvarez-Moises I, Perevyazko I, Lezov A, Guerrero-Santos C, Schubert US, Guerrero-Sanchez C (2017) Macromol Chem Phys 218:1700065
Visagie CM, Hirooka Y, Tanney JB, Whitfield E, Mwange K, Meijer M, Amend AS, Seifert KA, Smson RA (2014) Stud Mycol 78:63–139
Crameri R, Garbani M, Rhyner C, Huitema C (2014) 69: 176–185
Rodríguez-Carvajal JJ (1993) Phys B 192:55–69
Gómez-Cornelio S, Ortega-Morales O, Morón-Ríos A, Reyes-Estebanez M, De la Rosa-Garcia S (2016) Act Bot Mex 117:59–77
Clinical and Laboratory Standards Institute (CLSI) (2004) Method for antifungal well diffusion susceptibility Testing of Yeast M-44A
Hammer Ø, Harper DAT, Ryan PD (2001) Palaeontol Electron 4, 9
Liu HQ, Zong RW, Lo S, Hu Y, Zhi Y (2018) Procedia Eng 211:447–455
Siqueira JF, Lopes HP (1999) Int Endod J 32:361–369
Carmona-Ribeiro AM, Dias de Melo-Carrasco L (2013) Int J Mol Sci 14:9906–9946
Kourmouli A, Valenti M, Rijn van E, Beaumont JE, Kalantzi O-I, Schmidt-Ott A, Biskos G (2018) J Nanopart Res 20:62
Brotzmann V, Schuermann M, Katschmidt B, Kaltschmidt C, Sudhoff H (2017) J Microb Biochem Technol 9:249–256
This study was financially supported by the National Council for Science and Technology (Consejo Nacional de Ciencia y Tecnología [CONACYT, Mexico]) of the “Fronteras de la Ciencia No. 138” project and by the Community of Madrid under the “Climortec”, BIA2014−53911-R, “Geomaterials 2” Programme (S2013/MIT_2914), and Multimat Challenge (S2013/MIT-2862). A.S.-F. would like to gratefully acknowledge the financial support of Santander Universidades through “Becas Iberoamérica Jóvenes Profesores e Investigadores, España 2015” scholarship program. C.G.-S., R.Y.-M., and U.S.S. thank CONACYT and the Deutscher Akademischer Austauschdienst (DAAD, Germany) for financial support within the framework of the funding program for international mobility PROALMEX 2015 (CONACyT project: 267752 and DAAD project: 57271725). C.G.-S. and U.S.S. also thank the Deutsche Forschungsgemeinschaft (DFG, Germany) for financial support for this research under the scheme of the grant SFB-1278 “PolyTarget” project B02. The authors also thank D. Aguilar, A. Cristobal, and D. Huerta for their valuable technical support. We also thank Adrián Gómez Guerrero of the National Center for Electron Microscopy (CNME, Madrid, Spain) for the assistance provided and for its support with TEM characterization.
Conflict of interest
The authors declare that they have no conflict of interest.
About this article
Cite this article
Sierra-Fernandez, A., De la Rosa-García, S.C., Yañez-Macías, R. et al. Sol–gel synthesis of Mg(OH)2 and Ca(OH)2 nanoparticles: a comparative study of their antifungal activity in partially quaternized p(DMAEMA) nanocomposite films. J Sol-Gel Sci Technol 89, 310–321 (2019). https://doi.org/10.1007/s10971-018-4890-9
- Aspergillus niger
- Penicillium oxalicum
- Hydroxide nanoparticles
- Antifungal coatings
- Poly[(2-dimethylamino) ethyl methacrylate]