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Novel nanofiber membrane fabrication from konjac glucomannan and polydopamine via electrospinning method

  • Brief Communication: Nano-structured materials (particles, fibers, colloids, composites, etc.)
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Abstract

In this study, we synthesized a konjac glucomannan (KGM)/poly dopamine (PDA)/Oxaliplatin nanofiber membrane with efficient and controlled drug release properties by using electrospinning technology. The structure of the polymer network nanofiber membrane was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). KGM/PDA nanofiber membrane showed uniform sizes with an average diameter of 100–120 nm. The results revealed that the association of KGM and PDA to synthesize nanofiber membrane could be attributed to hydrogen bonds. Compared with KGM, the KGM/PDA nanofiber membrane exhibited higher moisture adsorption and drug release ability. Based on superior drug release ability, the KGM/PDA nanofibers provided a potential oxaliplatin carriers in application of drug release. This work contributed to a facile pathway on the construction of biomaterial nanofiber membrane by using polysaccharides.

Graphical abstract

Scheme 1. Schematic presentation of the preparation of KGM/PDA nanofiber membrane and the use for drug release.

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Scheme 1
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Acknowledgements

This research was financially supported by National Natural Science Foundation of China (No.31471704, 31772045) and the Scientific Research Foundation of Graduate School of Fujian Agriculture and Forestry University (324-1122yb034). The authors thank Su Chen for valuable discussion on preparation of the experiment.

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Authors and Affiliations

  1. College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China

    Lin Wang, Ruo-Jun Mu, Yi Yuan, Jingni Gong, Yongsheng Ni, Weihai Wang & Jie Pang

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  1. Lin Wang
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  2. Ruo-Jun Mu
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  3. Yi Yuan
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  4. Jingni Gong
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  5. Yongsheng Ni
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  6. Weihai Wang
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  7. Jie Pang
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Correspondence to Jie Pang.

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Wang, L., Mu, RJ., Yuan, Y. et al. Novel nanofiber membrane fabrication from konjac glucomannan and polydopamine via electrospinning method. J Sol-Gel Sci Technol 85, 253–258 (2018). https://doi.org/10.1007/s10971-017-4559-9

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  • DOI: https://doi.org/10.1007/s10971-017-4559-9

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