Abstract
Harmonic micro/nano-particles are very useful tool for in vivo bio-labeling applications due to their attractive properties. For example, they are free of blinking and photo bleaching, their excitation wavelength is continuously tunable and their signal is coherent. Here, we report the preparation of a new kind of harmonic microparticle, Ba2TiSi2O8 microparticle, based on the electrospraying technique. Morphology, crystalline structure, biocompatibility and optical property of the Ba2TiSi2O8 microparticles were investigated by scanning electron miscroscopy, transmission electron miscroscopy, X-ray diffraction, L929 cells incubation and pulsed laser irradiation. The results indicated that most of the Ba2TiSi2O8 microparticles prepared here sized in the 100 ~ 400 nm range, demonstrated good biocompatibility to L929 cells and presented efficient second-harmonic generation property, thus is promising as bio-labeling material.
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Chirlmin J, Hamza B, Yuji I, Chittanon B, Taekjip H (2008) Advances in single-molecule fluorescence methods for molecular biology. Annu Rev Biochem 77:51–76
Pinaud F, Clarke S, Sittner A, Dahan M (2010) Probing cellular events, one quantum dot at a time. Nat Methods 7(4):275–285
Bouzigues C, Gacoin T, Alexandrou A (2011) Biological applications of rare-earth based nanoparticles. ACS Nano 5(11):8488–8505
Masfer A, Yunyun C, Julie JP, Jorge MG, Dilworth YP, Philip RH, Hong L (2017) High resolution fluorescence bio-imaging upconversion nanoparticles in insects. Opt Express 25:1030–1039
Maldiney T, Lecointre A, Viana B, Bessière A, Bessodes M, Gourier D et al. (2011) Controlling electron trap depth to enhance optical properties of persistent luminescence nanoparticles for in vivo imaging. J Am Chem Soc 133(30):11810–11815
Chuang YJ, Zhen Z, Zhang F, Liu F, Mishra JP, Tang W, Chen H, Huang X, Wang L, Chen X, Xie J, Pan Z (2014) Photostimulable near-infrared persistent luminescent nanoprobes for ultrasensitive and longitudinal deep-tissue bio-Imaging. Theranostics 4(11):1112–1122
Maldiney T, Bessiere A, Seguin J, Teston E, Sharma SK, Viana B, Bos AJJ, Dorenbos P, Bessodes M, Gourier D, Scherman D, Richard C (2014) Luminescence and microscopy and molecular imaging and tissues - pubmed - ncbi. Gene Nat Mater 13(4):418–426
Mayer L, Slablab A, Dantelle G, Jacques V, Lepagnolbestel AM, Perruchas S et al. (2013) Single KTP nanocrystals as second-harmonic generation biolabels in cortical neurons. Nanoscale 5(18):8466–8471
Bonacina L, Magouroux T, Rogov A, Wolf JP, Staedler D, Passemard S et al. (2013) Harmonic nanoparticles for nonlinar bio-imaging and detection. Proc SPIE 8611(3):86110D1–8611D6D
Chang YR, Lee HY, Chen K, Chang CC, Tsai DS, Fu CC, Lim TS, Tzeng YK, Fang CY, Han CC, Chang HC, Fann W (2008) Mass production and dynamic imaging of fluorescent nanodiamonds. Nat Nanotechnol 3(5):284
Brokmann X, Hermier JP, Messin G, Desbiolles P, Bouchaud JP, Dahan M (2002) Statistical aging and nonergodicity in the fluorescence of single nanocrystals. Phys Rev Lett 90(12):120601
Bradac C, Gaebel T, Naidoo N, Sellars MJ, Twamley J, Brown LJ et al. (2010) Observation and control of blinking nitrogen-vacancy centres in discrete nanodiamonds. Nat Nanotechnol 5(5):345–349
Abdukayum A, Chen JT, Zhao Q, Yan XP (2013) Functional near infrared-emitting Cr3+/Pr3+ co-doped zinc gallogermanate persistent luminescent nanoparticles with superlong afterglow for in vivo targeted bioimaging. J Am Chem Soc 135(38):14125
Liu F (2013) Photostimulated near-infrared persistent luminescence as a new optical read-out from Cr3+-doped LiGa5O8. Sci Rep 3(3):1554
Campagnola PJ, Clark HA, Mohler WA, Lew LM, Lewis A (2001) Second-harmonic Imaging microscopy of living cells. J Biomed Opt 6(3):277–286
Bonacina L (2012) Nonlinear nanomedecine: harmonic nanoparticles toward targeted diagnosis and therapy. Mol Pharm 10(3):783–792
Floc’h VL, Brasselet S, Roch JF, Zyss J (2003) Monitoring of orientation in molecular ensembles by polarization sensitive nonlinear microscopy. J Phys Chem B 107:12403–12410
Magouroux T, Extermann J, Hoffmann P, Mugnier Y, Le DR, Jaconi ME et al. (2012) High-speed tracking of murine cardiac stem cells by harmonic nanodoublers. Small 8(17):2752–2756
Staedler D, Magouroux T, Passemard S, Ciepielewski D, Gerberlemaire S, Wolf JP, Bonacina L (2014) Assessment of cytotoxicity and oxidative effect of Bismuth Ferrite (BFO) harmonic nanoparticles for localized DNA photo-interaction. Proc SPIE 9165:916516-1–916516-6
Maruyama N, Honma T, Komatsu T (2009) Enhanced quantum yield of yellow photoluminescence of Dy3+ ions in nonlinear optical Ba2TiSi2O8, nanocrystals formed in glass. J Solid State Chem 182(2):246–252
Dong G, Liang M, Qin H, Chai G, Zhang X, Ma Z, Qiu J (2012) Controllable fabrication and broadband near-infrared luminescence of various Ni2+-activated ZnAl2O4 nanostructures by a single-nozzle electrospinning technique. Phys Chem Chem Phys 14(39):13594–13600
Niu C, Meng J, Wang X, Han C, Yan M, Zhao K, Zhang Q (2015) General synthesis of complex nanotubes by gradient electrospinning and controlled pyrolysis. Nat commun 6:7402
Acknowledgements
This work was financially supported by the National Natural Science Foundation of China (Grant No. 51302087, 51375444, 11404114), the Pearl River S&T Nova Program of Guangzhou (Grant No. 201610010119), and the Xiangjiang Scholar (Grant No. XJ2016051).
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Li, J., Zhang, H., Li, L. et al. Electrospraying preparation and characterization of harmonic Ba2TiSi2O8 microparticles. J Sol-Gel Sci Technol 83, 109–114 (2017). https://doi.org/10.1007/s10971-017-4361-8
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DOI: https://doi.org/10.1007/s10971-017-4361-8