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Evaluation of mesoporous silicate nanoparticles for the sustained release of the anticancer drugs: 5-fluorouracil and 7-hydroxycoumarin

  • Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
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Abstract

In this study, effects of chemical structure and molecular size of the anticancer drugs 5-fluorouracil and 7-hydroxycoumarin on their release from MCM-48 nanoparticles were investigated. Nanoparticles of the mesoporous silicate material, MCM-48, were prepared and characterized by XRD, SEM and FTIR. Loading of 5-fluorouracil and 7-hydroxycoumarin onto the nanoparticles was confirmed by FTIR and TGA measurements, and loading capacities of about 24 and 14 % were achieved, respectively. Release experiments for 5-fluorouracil were conducted in buffer solutions at pH = 7.4 and 5.2. However, due to the instability of 7-hydroxycoumarin in basic media, release experiments were conducted only in acidic buffer solution at pH = 5.2. The release of 5-fluorouracil was slightly affected by the pH of the release medium, and it was almost complete in about 2 h. However, the release of 7-hydroxycoumarin which has a larger size and higher acidity followed a prolonged release mode over a period of 12 h.

Graphical Abstract

The prolonged release of 7-hydroxycoumarin from MCM-48 nanoparticles points out to the potential use of this system as sustained release delivery carrier.

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Abbreviations

5-FU:

5-Fluorouracil

7-HC:

7-Hydroxycoumarin

DW:

Deionized water

MCM-48:

Mobil crystalline material no. 48

SBF:

Simulated body fluid

CTMB:

Cetyltrimethylammonium bromide

TEOS:

Tetraethylorthosilicate

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Acknowledgments

The authors are grateful to the financial support from Scientific Research Support Fund (Grant No. Bas/2/02/2012).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, The University of Jordan, Amman, 11942, Jordan

    Hamdallah A. Hodali, Dua’a M. Marzouqa & Fatma Z. Tekfa

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  1. Hamdallah A. Hodali
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  2. Dua’a M. Marzouqa
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  3. Fatma Z. Tekfa
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Correspondence to Hamdallah A. Hodali.

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Hodali, H.A., Marzouqa, D.M. & Tekfa, F.Z. Evaluation of mesoporous silicate nanoparticles for the sustained release of the anticancer drugs: 5-fluorouracil and 7-hydroxycoumarin. J Sol-Gel Sci Technol 80, 417–425 (2016). https://doi.org/10.1007/s10971-016-4127-8

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  • DOI: https://doi.org/10.1007/s10971-016-4127-8

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