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Functionalization of SBA-16 silica particles for ibuprofen delivery

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Abstract

In this study, the surface of the hydrothermally synthesized SBA-16 was modified with 3-aminopropyltriethoxysilane (APTES) as a controlled drug delivery system. In this case, ibuprofen was chosen as a drug. Furthermore, it was loaded into the SBA-16 base and functionalized SBA-16. Then, the adsorption and release properties of mention samples were studied. In addition, mesoporous materials were characterized using X-ray diffraction, fourier-transform infra-red spectroscopy, N2 adsorption/desorption analysis and ultra-violet spectroscopy. The results showed that adsorption and release behavior of ibuprofen were extremely depended on various surface properties of SBA-16 particles. Furthermore, it was observed that the sample with a higher percent loaded of ibuprofen exhibited a higher percent of the ibuprofen released molecules in a phosphate buffer solution.

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Acknowledgments

Authors gratefully thank Semnan University, and M. Shafiee Ardestani, M. R. Aghasadeghi in Department of Hepatitis B and HIV, Pasteur Institute of Iran for partially supporting the research work.

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Authors and Affiliations

  1. Materials Science and Engineering Department, Semnan University, P.O.Box 19111-35131, Semnan, Iran

    M. Naghiloo, M. Yousefpour, M. S. Nourbakhsh & Z. Taherian

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  1. M. Naghiloo
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  2. M. Yousefpour
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  3. M. S. Nourbakhsh
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  4. Z. Taherian
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Correspondence to M. Yousefpour.

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Naghiloo, M., Yousefpour, M., Nourbakhsh, M.S. et al. Functionalization of SBA-16 silica particles for ibuprofen delivery. J Sol-Gel Sci Technol 74, 537–543 (2015). https://doi.org/10.1007/s10971-015-3631-6

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