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Plasminogen activator entrapped within injectable alumina: a novel approach to thrombolysis treatment

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Abstract

A major obstacle in the development of new enzyme-based thrombolytic systems is their low stability and extremely short half-life (usually, less than 2–6 min of circulation half-life), which requires their administration in large doses to obtain therapeutic effects, and as a consequence, inevitably leads to a significant incidence of hemorrhagic complications. Here we point to a potential solution of this problem by developing a new family of injectable composites for thrombolysis: plasminogen activator entrapped within alumina, where alumina is a pertinent drug carrier developed to prolong activity in vivo and to reduce the total administered dose of the drug necessary for the treatment, and hence its side effects.

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Authors and Affiliations

  1. ITMO University, St. Petersburg, 197101, Russian Federation

    Vasiliy V. Vinogradov, Alexander V. Vinogradov, Vladimir E. Sobolev & Vladimir V. Vinogradov

  2. Petrozavodsk State University, Petrozavodsk, 185910, Russian Federation

    Ivan P. Dudanov

  3. Regional Vascular Center, St. Petersburg, Russian Federation

    Ivan P. Dudanov

Authors
  1. Vasiliy V. Vinogradov
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  2. Alexander V. Vinogradov
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  3. Vladimir E. Sobolev
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  4. Ivan P. Dudanov
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  5. Vladimir V. Vinogradov
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Corresponding author

Correspondence to Vladimir V. Vinogradov.

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Vinogradov, V.V., Vinogradov, A.V., Sobolev, V.E. et al. Plasminogen activator entrapped within injectable alumina: a novel approach to thrombolysis treatment. J Sol-Gel Sci Technol 73, 501–505 (2015). https://doi.org/10.1007/s10971-014-3601-4

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  • DOI: https://doi.org/10.1007/s10971-014-3601-4

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