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Large-scale synthesis of monodisperse microporous silica nanoparticles by gradual injection of reactants


Monodisperse microporous silica particles were prepared in high yield, by the gradual injection of tetramethoxysilane (TMOS) and template molecules into the reaction system. This resulted in continuous nucleation. The dilute TMOS concentration suppressed silica particle aggregation. The diameters of the microporous silica particles were 100–130 nm. The narrow size distribution resulted from larger particles experiencing smaller growth rates, despite the continuous nucleation occurring during TMOS injection. This method has potential in the industrial-scale preparation of monodisperse silica particles.

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  1. Stöber W, Fink A (1968) J Colloid Interface Sci 26:62–69

    Article  Google Scholar 

  2. Unger KK, Kreysa G (2000) Characterisation of Porous Solids V. Elsevier, pp 155–165

  3. Unger KK, Kumar D, Grün M, Büchel G, Lüdtke S, Adam Th, Schumacher K, Renker S (2000) J Chromatogr A 892:47–55

    Article  Google Scholar 

  4. Shiratori Y, Saito H, Higuchi M, Katayama K, Azuma Y (2002) J Ceram Soc Jpn 110:304–309

    Article  Google Scholar 

  5. Shiratori Y, Saito H, Higuchi M, Asaka T, Katayama K, Azuma Y (2003) J Ceram Soc Jpn 111:104–109

    Article  Google Scholar 

  6. Yano K, Suzuki N, Akimoto Y, Fukushima Y (2002) Bull Chem Soc Jpn 75:1977–1982

    Article  Google Scholar 

  7. Yano K, Fukushima Y (2003) J Mater Chem 13:2577–2581

    Article  Google Scholar 

  8. Yano K, Fukushima Y (2004) J Mater Chem 14:1579–1584

    Article  Google Scholar 

  9. Yamada Y, Yano K (2006) Micro Mesoam Mater 93:190–198

    Article  Google Scholar 

  10. Nakamura T, Mizutani M, Nozaki H, Suzuki N, Yano K (2007) J Phys Chem C 111:1093–1100

    Article  Google Scholar 

  11. Mizutani M, Yamada Y, Nakamura T, Yano K (2008) Chem Mater 20:4777–4782

    Article  Google Scholar 

  12. Yano K, Katz MB, Pan X, Tatsuda N (2014) J Colloid Interface Sci 418:61–65

    Article  Google Scholar 

  13. Urata C, Aoyama Y, Tonegawa A, Yamauchi Y, Kuroda K (2009) Chem Commun 34:5094–5096

    Article  Google Scholar 

  14. Qiao Z-A, Zhang L, Guo M, Liu Y, Huo Q (2009) Chem Mater 21:3823–3829

    Article  Google Scholar 

  15. Yamada H, Urata C, Aoyama Y, Osada S, Yamauchi Y, Kuroda K (2012) Chem Mater 24:1462–1471

    Article  Google Scholar 

  16. Kuroda K, Shimojima A, Kawahara K, Watabayashi R, Yamura Y, Asakura Y, Kitahara M (2014) Chem Mater 26:211–220

    Article  Google Scholar 

  17. Nooney RI, Thirunavukkarasu D, Chen Y, Josephs R, Ostafin AE (2002) Chem Mater 12:4721–4728

    Article  Google Scholar 

  18. Suzuki K, Ikari K, Imai H (2004) J Am Chem Soc 126:462–463

    Article  Google Scholar 

  19. Ikari K, Suzuki K, Imai H (2004) Langmuir 20:11504–11508

    Article  Google Scholar 

  20. Ikari K, Suzuki K, Imai H (2006) Langmuir 22:802–806

    Article  Google Scholar 

  21. Zhang K, Xu LL, Jiang JG, Calin N, Lam KF, Zhang SJ, Wu HH, Wu GD, Albela B, Bonneviot L, Wu P (2013) J Am Chem Soc 135:2427–2430

    Article  Google Scholar 

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Correspondence to Masahide Takahashi.

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Shimogaki, T., Tokoro, H., Tabuchi, M. et al. Large-scale synthesis of monodisperse microporous silica nanoparticles by gradual injection of reactants. J Sol-Gel Sci Technol 74, 109–113 (2015).

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