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Silica from rice husks employed as drug delivery for folic acid

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Abstract

Silica was obtained from rice husk, this type of silica is also known as SiO2-rice, was investigated as drug delivery for the folic acid. The SiO2-rice was obtained from calcinations at 600 °C and its textural properties were compared with mesoporous silica (MS). The maximum folic acid adsorption on SiO2-rice was at the 18 % weight, while MS adsorbs 19 % weight. An important pH effect on the drug released was observed; both silicas released around 35 % of acid folic at pH 7, while at pH 3 only 3 % of the drug was released. Differential Thermal Analyzer analysis suggests that the folic acid was not crystallized into the porous of the silica; therefore, it is possible that the drug was trapped within the complex network of pores preventing their full release. However, the drug released for 400 μg of folic acid, a commercial dose, indicated that until 93 % of drug could be released for the silicas at pH of 5.5; a minor desorption was observed by commercial tablet.

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References

  1. Ukmar T, Planinsek O (2010) Acta Pharm 60:373–385

    Article  Google Scholar 

  2. De Muth P, Hurley M, Wu Ch, Galanie S, Zachariah MR, Deshong P (2011) Microporous Mesoporous Mater 141:128–134

    Article  Google Scholar 

  3. Trewyn BG, Nieweg JA, Zhao Y, Lin VSY (2008) Chem Eng J 137:23–29

    Article  Google Scholar 

  4. Kortesuo P, Ahola M, Karlsson S, Kangasniemi I, Yli-Urpo I, Kiesvaara J (2000) Biomaterialas 21:193–198

    Article  Google Scholar 

  5. Anderson J, Rosenholm J, Linden M (2008) In: Ashammaki N (ed) mesoporous silica: an alternative diffusion controlled drug delivery, e-book

  6. Mortera R, Fiorilli S, Garrone E, Verné E, Onida B (2010) Chem Eng J 156:184–192

    Article  Google Scholar 

  7. Valler-Regí M, Doadrio JC, Doadrio AL, Izquierdo-Barba I, Pérez-Pariente J (2004) Na State Ion 172:435–439

    Article  Google Scholar 

  8. Suriyanon N, Punyapalakul P, Ngamcharussrivichai Ch (2013) Chem Eng J 214:208–218

    Article  Google Scholar 

  9. Vialpando M, Backhuijs F, Martens JA, den Mooter GV (2012) Eur J Pharm Biopharm 81:190–198

    Article  Google Scholar 

  10. Sanganwar GP, Gupa RB (2008) Int J Pharm 360:213–218

    Article  Google Scholar 

  11. Mellaerts R, Mols R, Jammaer JAG, Aerts CA, Annaert P, Humbeeck JV, den Mooter GV, Augustijns P, Martens JA (2008) Eur J Pharm Biopharm 69:223–230

    Article  Google Scholar 

  12. Wu C, Wang J, Hu Y, Jiang T, Zhang J, Wang S (2012) Mater Sci Eng C 32:201–206

    Article  Google Scholar 

  13. Zhang Y, Wang J, Bai X, Jiang T, Zhang Q, Wang S (2012) Mol Pharm 9:505–513

    Article  Google Scholar 

  14. Zhao P, Wang L, Sun C, Jiang T, Zhang J, Zhang Q, Sun J, Deng Y, Wang S (2012) Eur J Pharm Biopharm 80:535–543

    Article  Google Scholar 

  15. Tang Q, Chen Y, Chen J, Li J, Xu Y, Wu D, Sun Y (2010) J Solid State Chem 183:76–83

    Article  Google Scholar 

  16. Szegedi A, Popova M, Goshev I, Mihaly J (2011) J Solid State Chem 184:1201–1207

    Article  Google Scholar 

  17. Slowing I, Trewyn BG, Lin VSY (2006) J Am Chem Soc 128:14792–14793

    Article  Google Scholar 

  18. Manzano M, Aina V, Arean CO, Balas F, Cauda V, Colilla M, Delgado MR, Vallet-Regí M (2008) Chem Eng J 137:30–37

    Article  Google Scholar 

  19. Liou TH (2004) Mater Sci Eng A 364:313–323

    Article  Google Scholar 

  20. Arcos CA, Pinto DM, Rodriguez-Paéz JE (2007) Rev Fac Ing Univ Antioqui 41:7–20

    Google Scholar 

  21. Bansal V, Ahmad A, Sastry M (2006) J Am Chem Soc 128:14059–14066

    Article  Google Scholar 

  22. Zhu T, Koepsel R, Omach MM, Ataai MM (2003) In: Saha BC (ed) Fermentation biotechnology. ACS Symp Series, vol 862

  23. Wolfgarten E, Putz B, Holscher AH, Bollschweiler E (2007) J Gastrointest Surg 11:479–486

    Article  Google Scholar 

  24. Mcloy RF, Greenberg GR, Baron JH (1984) Gut 25:386–392

    Article  Google Scholar 

  25. Ray JG, Meier C, Vermeulen S, Boss S, Wyatt PR, Cole DE (2002) Lancet 360:2047–2048

    Article  Google Scholar 

  26. Lin HP, Mou CY (2002) Acc Chem Res 35:927–935

    Article  Google Scholar 

  27. Mokhonoana MP, Coville NJ (2010) J Sol–Gel Sci Technol 54:83–92

    Article  Google Scholar 

  28. Launer PJ (2008) In: Arkles B, Lardson G (eds) Infrared analysis of organosilicon compounds: spectra-structure correlation. Gelest INC, Morrisville

    Google Scholar 

  29. Battisha IK, Beyally AE, Mongy SE, Nahrawi AM (2007) J Sol–Gel Sci Technol 41:129–137

    Article  Google Scholar 

  30. Rámila A, Muñoz B, Pérez-Pariente J (2003) Vallet-Regí. J Sol–Gel Sci Technol 26:1199–1202

    Article  Google Scholar 

  31. Salazar-Hernández C, Zarraga R, Alonso S, Sugita S, Calixto S, Cervantes J (2009) J Sol–Gel Sci Technol 49:301–310

    Article  Google Scholar 

  32. Speybroeck MV, Barillaro V, Thi TD, Mellaerts R, Martens J, Humbeeck JV, Vermant J, Annaert P, Mooter GVD, Augustijns P (2009) J Pharm Sci 98:2648–2658

    Article  Google Scholar 

Download references

Acknowledgments

The authors wish to acknowledge the financial support of the Instituto Politécnico Nacional through grant SIP-20130874. Also, acknowledge to Rocío Lona Ramos for her technical support in this work.

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Authors and Affiliations

  1. Departamento de Ingeniería en Minas, Metalurgia y Geología, División de Ingenierías Universidad de, Guanajuato, 3600, Mexico

    Mercedes Salazar Hernández, Enrique Elorza & María J. Puy Alquiza

  2. UPIIG, Instituto Politécnico Nacional, 36275 Silao de la Victoria Gto, Guanajuato, Mexico

    Carmen Salazar Hernández & Marcelino Carrera-Rodríguez

  3. Departamento de Química, División de ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, 36050, Mexico

    Alfredo Gutiérrez Fuentes

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  1. Mercedes Salazar Hernández
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  2. Carmen Salazar Hernández
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  3. Alfredo Gutiérrez Fuentes
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  4. Enrique Elorza
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  5. Marcelino Carrera-Rodríguez
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  6. María J. Puy Alquiza
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Correspondence to Mercedes Salazar Hernández.

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Salazar Hernández, M., Salazar Hernández, C., Gutiérrez Fuentes, A. et al. Silica from rice husks employed as drug delivery for folic acid. J Sol-Gel Sci Technol 71, 514–521 (2014). https://doi.org/10.1007/s10971-014-3378-5

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  • DOI: https://doi.org/10.1007/s10971-014-3378-5

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