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Synthesis, characterization and preliminary toxicity assays of NIR-active Au-silicate nanoparticles through a sol-gel processing

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Abstract

Monodisperse Au-silicate nanoparticles (10.7±1.6 nm in diameter) were prepared by reduction of aqueous solution containing 2 mM HAuCl4 with sodium citrate (1 wt.%) in a hydrosol, in which small clusters of silicate formed by hydrolysis and polymerization of 3-aminopropyltrimethoxysilane (APTMS). APTMS covalently linked to reduced gold particles through its -NH2 end-group. UV-vis spectra of the obtained Au-silicate nanoparticles showed a peak at ∼690 nm due to the interface effects between the Au and the silicate matrix. The Au-silicate nanoparticles exhibited near-IR (NIR) sensitivity. Cytotoxicity and limited hemocompatibility in vitro for the prepared Au-silicate nanoparticles were also investigated. It was shown that at lower concentration (<1 μg/ml), the Au-silicate nanoparticles were biocompatible without causing any cytotoxicity and hemolysis.

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Authors and Affiliations

  1. Research Center of Biomedical Engineering, Medical College, Xiamen University, Xiamen, 361005, P.R. China

    Lei Ren & Qi-Qing Zhang

  2. Department of Materials Science and Engineering, National University of Singapore, Singapore, 119260

    Gan-Moog Chow

Authors
  1. Lei Ren
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  2. Qi-Qing Zhang
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  3. Gan-Moog Chow
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Correspondence to Lei Ren.

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Ren, L., Zhang, QQ. & Chow, GM. Synthesis, characterization and preliminary toxicity assays of NIR-active Au-silicate nanoparticles through a sol-gel processing. J Sol-Gel Sci Technol 39, 269–274 (2006). https://doi.org/10.1007/s10971-006-8158-4

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  • DOI: https://doi.org/10.1007/s10971-006-8158-4

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