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Recent progress in ruthenium chemistry for establishing a 103Ru/103mRh generator for Auger therapy

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Abstract

The most challenging task for establishing a 103Ru/103mRh generator for Auger therapy, is to reach an effective separation between the two radionuclides because of the highly unpredictable, very complicated and poorly understood chemistry. In HCl, this work was able to evidence the formation of Ru colloids. It has been evidenced that the starting material of Ru, time and temperature have a strong influence on Ru speciation, but no polynuclear species of ruthenium–chloride was observed. This work has showed that it is fully possible to control the speciation of ruthenium, especially Ru(IV), within a mononuclear species; that is a huge step forward compared to literature.

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Data availability statement

Data available on request due to restrictions e.g. privacy or ethical. The data presented in this study are available on request from the corresponding author. The data are not publicly available due to their extended size, incompatible with online upload.

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Acknowledgements

This work has been supported in part by grants from the French National Agency for Research, called “Investissements d’Avenir” IRON Labex no. ANR-11-LABX-0018-01 and ArronaxPlus Equipex no. ANR-11-EQPX-0004. The authors thank the mass spectrometry platform INRAE BIBS (BIA research unit, Nantes, https://www.bibs.inrae.fr) for the analyses performed.

Funding

Agence Nationale de la Recherche, ANR-11-LABX-0018-01, ANR-11-EQPX-0004.

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Authors and Affiliations

  1. SUBATECH, UMR 6457, Nantes Université, IMT Atlantique/CNRS-IN2P3, Nantes Université, 4 Rue A. Kastler, BP 20722, 44307, Nantes Cedex 3, France

    Marie Théry & Sandrine Huclier-Markai

  2. GIP ARRONAX, 1 Rue Arronax – CS 10112, 44817, Saint-Herblain Cedex, France

    Marie Théry, Cyrille Alliot & Sandrine Huclier-Markai

  3. INSERM U892, 8 Quai Moncousu, BP 70721, 44007, Nantes Cedex 1, France

    Cyrille Alliot

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  1. Marie Théry
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Contributions

Conceptualization, S.H.-M., C.A.; methodology, S.H.-M., C.A.; software, C.A., M.T.; validation, S.H.-M., C.A.; formal analysis, M.M.; investigation, M.M.; resources, C.S.; data curation, S.H.-M., C.A., M.T.; writing—original draft preparation, S.H.-M., C.A., M.M., writing—review and editing, S.H-M.; visualization, S.H.-M.; supervision, S.H.-M., C.A.; project administration, S.H-M.; funding acquisition, S.H.-M.

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Correspondence to Sandrine Huclier-Markai.

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The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Théry, M., Alliot, C. & Huclier-Markai, S. Recent progress in ruthenium chemistry for establishing a 103Ru/103mRh generator for Auger therapy. J Radioanal Nucl Chem (2024). https://doi.org/10.1007/s10967-024-09484-9

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