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Potential of [99mTc] Tc-IONPs in SPECT: a systematic review on efficiency and accumulation rates

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Abstract

The aim of this study is to compare the efficiency and accumulation of 99mTc attached to iron oxide nanoparticles (IONPs) for use in the SPECT imaging. A comprehensive literature search identified 13 relevant studies, and the maximum absorbed dose per gram (ID/g) of [99mTc] Tc-IONPs in various organs at different time intervals was analyzed. The findings showed the distribution patterns of the compounds in each organ, emphasizing the significance of coating and nanoparticle size for optimal imaging results. By selecting the appropriate coating and nanoparticle size, imaging quality and accuracy can be improved.

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  1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Javad Garshad, Ali Salarvand, Morteza Tavakoli & Mahsa Mansourian

  2. Department of General Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Morteza Tavakoli

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Garshad, J., Salarvand, A., Tavakoli, M. et al. Potential of [99mTc] Tc-IONPs in SPECT: a systematic review on efficiency and accumulation rates. J Radioanal Nucl Chem (2024). https://doi.org/10.1007/s10967-024-09480-z

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