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Full automation of the radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) on the ALL IN ONE synthesizer

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Abstract

N-Succinimidyl-4-[18F]fluorobenzoate, also known as [18F]SFB, is a secondary labeling and imaging agent that has been developed for imaging applications in the Positron Emission Tomography (PET). A fully optimized and configured preparation procedure, including reaction factors, and designed a robust program for the synthesis. The program has undergone several modifications to ensure a smooth and automated synthesis program consisting of multiple steps. Comparable radiochemical yields (32–57% ± 5%, n = 25) to previously reported procedures are achieved with acceptable reaction time and high radiochemical purity (> 98%).

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Acknowledgements

The author thanks King Faisal Specialist Hospital and Research Centre (KFSH&RC) for providing the practical instruments and to Mr. Y. AlMalki for his technical assistance (RAC # 21900 31).

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  1. Cyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

    Mohammed Al-Qahtani

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Al-Qahtani, M. Full automation of the radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) on the ALL IN ONE synthesizer. J Radioanal Nucl Chem (2024). https://doi.org/10.1007/s10967-024-09355-3

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