Skip to main content
SpringerLink
Log in

Primary activity standardization of 18F for the calibration of the KRISS ionization chamber

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

A primary activity standardization of 18F was carried out at KRISS by means of the 4πβ(LS)-γ coincidence counting with a combined standard uncertainty of 0.31%. The activity value was compared with those obtained from the TDCR method, which was performed as a confirmatory measurement of the standardization. The final massic activity value of (13.186 ± 0.041) MBq·g‑1 at k = 1 was found and used as the reference value to calibrate the KRISS reference ionization chamber employed as the secondary measurement standard of 18F. The calibration result was then compared with the existing calibration factor that was obtained from the efficiency curve of the reference ionization chamber.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Boellaard R, Delgado-Bolton R, Oyen WJ, Giammarile F, Tatsch K, Eschner W, Verzijlbergen FJ, Barrington SF, Pike LC, Weber WA, Stroobants S, Delbeke D, Donohoe KJ, Holbrook S, Graham MM, Testanera G, Hoekstra OS, Zijlstra J, Visser E, Hoekstra CJ, Pruim J, Willemsen A, Arends B, Kotzerke J, Bockisch A, Beyer T, Chiti A, Krause BJ (2015) European association of nuclear medicine (EANM), FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imag. https://doi.org/10.1007/s00259-014-2961-x

    Article  Google Scholar 

  2. Schrader H (1997) Monographie BIPM-4 activity measurements with ionization chambers. BIPM, Sèvres

    Google Scholar 

  3. Kim E-J, Park TS, Lee JM, Hahm DS, Lee KB (2012) Standardization of 18F by digital coincidence counting. Appl Radiat Isot. https://doi.org/10.1016/j.apradiso.2012.03.028

    Article  PubMed  Google Scholar 

  4. Chisté V, Bé MM, Kuzmenko NK (2023) Table of radionuclides. F-18. http://www.lnhb.fr/nuclides/F-18_tables.pdf. Accessed 15 Mar 2023

  5. Schrader H, Klein R, Kossert K (2007) Activity standardisation of 18F and ionisation chamber calibration for nuclear medicine. Appl Radiat Isot. https://doi.org/10.1016/j.apradiso.2007.01.002

    Article  PubMed  Google Scholar 

  6. Sahagia M, Ioan R, Luca A, Antohe A, Ivan C, Neascu B, Ghioca C (2014) Standardization of 18F and its use for the Romanian PET metrological traceability chain assurance. Appl Radiat Isot. https://doi.org/10.1016/j.apradiso.2013.11.047

    Article  PubMed  Google Scholar 

  7. Capogni M, Carconi P, De Felice P, Fazio A (2016) 18F primary standard at ENEA-INMRI by three absolute techniques and calibration of a well-type IG11 ionization chamber. Appl Radiat Isot. https://doi.org/10.1016/j.apradiso.2015.12.055

    Article  PubMed  Google Scholar 

  8. van Rooy MW, van Staden MJ, Simpson BRS, Lubbe J (2020) Activity determination of 18F using liquid scintillation beta-efficiency extrapolation and non-extrapolation methods. Appl Radiat Isot. https://doi.org/10.1016/j.apradiso.2020.109070

    Article  PubMed  Google Scholar 

  9. Report ICRU (1994) Particle counting in radioactivity measurements. International Commission on Radiation Units and Measurements, Bethesda

    Google Scholar 

  10. Fitzgerald R, Bailat C, Bobin C, Keightley JD (2015) Uncertainties in 4πβ-γ coincidence counting. Metrologia. https://doi.org/10.1088/0026-1394/52/3/S86

    Article  Google Scholar 

  11. Lee KB, Lee JM, Park TS, Lee SH (2010) Development of a high-efficiency 4πβ(LS)-γ coincidence system for direct measurements of activity in radioactive decay. IEEE Trans Nucl Sci. https://doi.org/10.1109/TNS.2010.2040753

    Article  PubMed  PubMed Central  Google Scholar 

  12. Lee KB, Lee JM, Park TS, Oh PJ, Lee SH, Lee MK (2011) Application of digital sampling techniques for 4πβ (LS)-γ coincidence counting. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers Detect Assoc Equip 626:72–76

    Article  Google Scholar 

  13. James F, Roos M (1975) Minuit - a system for function minimization and analysis of the parameter errors and correlations. Comput Phys Commun. https://doi.org/10.1016/0010-4655(75)90039-9

    Article  Google Scholar 

  14. Baerg AP (1973) The efficiency extrapolation method in coincidence counting. Nucl Instruments Methods. https://doi.org/10.1016/0029-554X(73)90788-X

    Article  Google Scholar 

  15. Fitzgerald R, Zimmerman BE, Bergeron DE, Cessna JC, Pibida L, Moreira DS (2014) A new NIST primary standardization of 18F. Appl Radiat Isot. https://doi.org/10.1016/j.apradiso.2013.11.116

    Article  PubMed  Google Scholar 

  16. Lee KB, Lee JM, Park TS, Hwang HY (2004) Implementation of TDCR method in KRISS. Nucl Instruments Methods Phys Res Sect A Accel Spectrometers, Detect Assoc Equip. https://doi.org/10.1016/j.nima.2004.06.150

    Article  Google Scholar 

  17. Agusbudiman A, Lee KB, Lee JM, Hwang SH, Kim BJ (2022) Development of FPGA-based coincidence module for TDCR counting system. Radiat Phys Chem. https://doi.org/10.1016/j.radphyschem.2022.110377

    Article  Google Scholar 

  18. Broda R (2003) A review of the triple-to-double coincidence ratio (TDCR) method for standardizing radionuclides. Appl Radiat Isot. https://doi.org/10.1016/S0969-8043(03)00056-3

    Article  PubMed  Google Scholar 

  19. Bouchard J, Cassette P (2000) MAC3: an electronic module for the processing of pulses delivered by a three photomultiplier liquid scintillation counting system. Appl Radiat Isot. https://doi.org/10.1016/S0969-8043(99)00228-6

    Article  PubMed  Google Scholar 

  20. NEA (2019) PENELOPE 2018: a code system for monte carlo simulation of electron and photon transport. NEA, Barcelona

    Google Scholar 

  21. Report ICRU (1984) Stopping powers for electrons and positrons. International commission on radiation units and measurements, Bethesda

    Google Scholar 

  22. PerkinElmer LSC in Practice (2023) LSC Cocktails-Elemental Composition. https://resources.perkinelmer.com/lab-solutions/resources/docs/APP_LSCCocktailsElementalComposition.pdf. Accessed 15 Mar 2023

  23. Lee JM, Lee KB, Lee SH, Park TS (2012) Calibration of KRISS reference ionization chamber for key comparison of 99mTc measurement. Appl Radiat Isot. https://doi.org/10.1016/j.apradiso.2012.02.026

    Article  PubMed  Google Scholar 

  24. Broda R, Małetka K, Terlikowska T, Cassette P (2002) Study of the influence of the LS-cocktail composition for the standardisation of radionuclides using the TDCR model. Appl Radiat Isot. https://doi.org/10.1016/S0969-8043(01)00202-0

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thank the Korea Research Institute of Standards and Science (KRISS) for supporting this research activity. This study was presented at the International Conference on Nuclear Analytical Techniques in 2022 (NAT2022), which was held in Daejeon, Korea, from Dec. 7 to 9, 2022.

Author information

Authors and Affiliations

  1. Ionizing Radiation Metrology Group, Korea Research Institutes of Standards and Science (KRISS), 267 Gajeong-Ro Yuseong-Gu, Daejeon, 34113, Republic of Korea

    Agung Agusbudiman, Kyoung Beom Lee, Jong Man Lee, Sanghoon Hwang, Byoung Chul Kim & Dong Hye Heo

  2. Department of Science of Measurement, University of Science and Technology (UST), 217 Gajeong-Ro Yuseong-Gu, Daejeon, 34113, Republic of Korea

    Agung Agusbudiman, Kyoung Beom Lee, Jong Man Lee & Sanghoon Hwang

Authors
  1. Agung Agusbudiman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kyoung Beom Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jong Man Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sanghoon Hwang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Byoung Chul Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dong Hye Heo
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

AA: Conceptualization, Methodology, Investigation, Software, Formal analysis, Data curation, Visualization, Writing – Original Draft, Writing – Review & Editing. KBL: Conceptualization, Methodology, Software, Formal analysis, Validation, Supervision, Writing – Review & Editing, Funding acquisition. JML: Investigation, Data curation, Validation, Writing – Review & Editing. SH: Project administration, Supervision, Funding acquisition, Validation, Writing – Review & Editing. BCK: Investigation, Resources. DHH: Resources.

Corresponding author

Correspondence to Kyoung Beom Lee.

Ethics declarations

Conflict of interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Agusbudiman, A., Lee, K.B., Lee, J.M. et al. Primary activity standardization of 18F for the calibration of the KRISS ionization chamber. J Radioanal Nucl Chem 332, 5259–5265 (2023). https://doi.org/10.1007/s10967-023-09099-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-023-09099-6

Keywords

Search

Navigation