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Mismatch of FAPI PET/CT and FDG PET/CT in evaluating TARE treatment on a rat model of liver cancer

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Abstract

Tumorous fibrosis, such as desmoplasia and fibrous hyperplasia, is a typical characteristic led by interventional embolization and selective internal radiotherapy. In this study, 68Ga-FAPI-04 PET/CT was used to evaluate in situ hepatocellular carcinoma of rat models after TARE operation and compared with 18F-FDG PET/CT. The results showed that the reflection of pathological changes in fibrosis by 68Ga-FAPI-04 PET/CT depends on the time-points of postoperative imaging in evaluating tumor treated with TARE. Conclusively, 68Ga-FAPI-04 PET/CT can be used to assess fibrosis changes after TARE and correspond to pathological changes, providing an important supplement to the current assessment with 18F-FDG PET/CT.

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Authors and Affiliations

  1. Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, 310005, Zhejiang, China

    Linlin Shi & Qingqing Han

  2. Department of Nuclear Medicine, Shanghai Changhai Hospital, Shanghai, 200433, China

    Rou Li, Xiao Li & Guorong Jia

  3. Cancer Center, Department of Radiology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China

    Yang Zhang & Dong He

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  1. Linlin Shi
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  2. Rou Li
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  5. Xiao Li
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Correspondence to Guorong Jia or Dong He.

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Shi, L., Li, R., Han, Q. et al. Mismatch of FAPI PET/CT and FDG PET/CT in evaluating TARE treatment on a rat model of liver cancer. J Radioanal Nucl Chem 332, 2921–2928 (2023). https://doi.org/10.1007/s10967-023-09009-w

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  • DOI: https://doi.org/10.1007/s10967-023-09009-w

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