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Production assessment of 195mPt in Tehran research reactor

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Abstract

Platinum compounds are the main chemotherapeutic agents used in cancer treatment. 195mPt is a promising theranostic radionuclide for targeted radionuclide therapy. This study presents 195mPt production through neutron activation of natural Platinum target in Tehran Research Reactor. Theoretical production yield of 195mPt was calculated through simultaneous solution of differential equations of decay chains, and also simulation with MCNPX. Theoretical results were compared with experimental values. Moreover, liquid–liquid extraction using ethyl acetate was used for chemical separation. The results showed a good agreement between the experimental and theoretical values. In addition, high separation efficiency (> 99%) was achieved via solvent extraction separation.

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Acknowledgements

The utilized official MCNPX 2.6.0 license was under National Nuclear EnergyAgency (BATAN) of Indonesia. Authers are thankful to BATAN for their support.

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Authors and Affiliations

  1. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), North Kargar Street, Box 14395-836, Tehran, Iran

    Sara Vosoughi, Mohammad Reza Aboudzadeh Rovias, Ali Rahiminezhad, Fatemeh Bolouri Novin & Kamran Yousefi

  2. Center of Science and Technology Accelerator, National Nuclear Energy of Indonesia (BATAN), Yogyakarta, Indonesia

    Yohannes Sardjono

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  1. Sara Vosoughi
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  2. Mohammad Reza Aboudzadeh Rovias
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  3. Ali Rahiminezhad
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  4. Fatemeh Bolouri Novin
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  5. Kamran Yousefi
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  6. Yohannes Sardjono
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Correspondence to Mohammad Reza Aboudzadeh Rovias.

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Vosoughi, S., Rovias, M.R.A., Rahiminezhad, A. et al. Production assessment of 195mPt in Tehran research reactor. J Radioanal Nucl Chem 332, 2989–2994 (2023). https://doi.org/10.1007/s10967-023-09008-x

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