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A double cartridge approach increased the [11C]methionine radiochemical yield by 20%

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Abstract

11C-labelled L-methionine is a promising radiotracer for detecting brain tumors. In this study, we have devised a novel approach for [11C]methionine radiosynthesis and observed its impact on the final radiochemical yield. We found an increase of 20% in the final radiochemical yield of [11C]methionine when synthesized using double cartridge approach. The yield was significantly higher when compared with single cartridge method (p < 0.01). In conclusion, we successfully increased the yield of [11C]methionine by using the double cartridge approach.

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Acknowledgements

The work was supported by Science and Engineering Research Board grant (SERB/007/303/2019/01256), India. We also thank Aadarsh Singh, CHEP, IISc for providing valuable comments during the writing of this manuscript and his knowledge and insights are greatly appreciated.

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Authors and Affiliations

  1. Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences (NIMHANS), Hosur Road, Bengaluru, Karnataka, 560029, India

    Aishwarya Kumar, Pardeep Kumar, Riptee Thakur, Raman Kumar Joshi & Gopinath R

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  1. Aishwarya Kumar
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  2. Pardeep Kumar
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  3. Riptee Thakur
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  4. Raman Kumar Joshi
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  5. Gopinath R
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Correspondence to Aishwarya Kumar.

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Kumar, A., Kumar, P., Thakur, R. et al. A double cartridge approach increased the [11C]methionine radiochemical yield by 20%. J Radioanal Nucl Chem 332, 1961–1967 (2023). https://doi.org/10.1007/s10967-023-08891-8

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  • DOI: https://doi.org/10.1007/s10967-023-08891-8

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