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Highly selective separation of medical isotope 99mTc from irradiated 100Mo target using PEG-based resins

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Abstract

The aim of present study was to determine the efficiency of commercially available PEG-based resins for separation of 99mTc from irradiated 100Mo target. Stable and radioactive tracer studies demonstrated that these PEG-based resins have extreme selectivity toward ReO4− (99mTcO4−) over MoO42− ions. Moreover, PEG-based resins still have 95% adsorption efficiency even after 600 kGy γ-irradiation, suggesting the excellent irradiation stability. The adsorption rate of ReO4− and 99mTcO4− rapidly increased to 90% in 10 s. Subsequently, three-column chromatographic processing based on these superior resins for isolating 99mTc was developed and examined. The separation investigation of 99mTc medical radioisotope produced by 100Mo(p, 2n)99mTc reaction was successfully performed. The recovery yield and the radionuclidic purity of 99mTc was about 90% and 99.9%, respectively. Moreover, the separation of 99mTc from a low specific activity 99Mo was also investigated. We are excited about the potential of this procedure with these accessible commercial availability PEG-based resins to address 99mTc separation problems and increase access to medical nuclide 99mTc for the general community.

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Acknowledgements

This research is supported by Competitive projects of the special fund for the guidance of the innovation and development of science and technology, Gansu Province. (Investigation on Preparation and Separation technology of the Medical Isotope based on the high-current Accelerator)

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Authors and Affiliations

  1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China

    Fangli Fan, Nianwei Cheng, Zhuofan Jin, Desheng Chen, Wei Tian, Qinggang Huang, Shiwei Cao, Cunmin Tan, Jieru Wang, Xiaolei Wu, Jing Bai & Zhi Qin

  2. Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, 516003, China

    Fangli Fan, Desheng Chen, Wei Tian, Qinggang Huang, Shiwei Cao, Cunmin Tan, Jieru Wang, Xiaolei Wu, Jing Bai & Zhi Qin

  3. School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100010, China

    Fangli Fan, Zhuofan Jin, Desheng Chen, Jieru Wang & Zhi Qin

  4. School of Nuclear Science and Technology, Lanzhou University, Lanzhou, 730000, China

    Nianwei Cheng & Jieru Wang

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  1. Fangli Fan
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Fan, F., Cheng, N., Jin, Z. et al. Highly selective separation of medical isotope 99mTc from irradiated 100Mo target using PEG-based resins. J Radioanal Nucl Chem 332, 1113–1123 (2023). https://doi.org/10.1007/s10967-023-08771-1

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