Abstract
Separation technique of rhenium radioisotopes from a deuteron-irradiated tungsten target of natural isotopic composition has been developed. The irradiated tungsten powder was dissolved in a mixture of H2O2 and NaOH, the solution was passed through a column filled with an extraction chromatographic sorbent TEVA Resin. Rhenium was eluted with 4 M nitric acid. The separation procedure takes approximately 3 h, the radiochemical yield of rhenium is more than 97%.
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Denis-Bacelar AM, Chittenden SJ, Mccready VR et al (2018) Bone lesion absorbed dose profiles in patients with metastatic prostate cancer treated with molecular radiotherapy. Br J Radiol 91. https://doi.org/10.1259/bjr.20170795
Lam MGEH, De Klerk JMH, Van Rijk PP (2004) 186Re-HEDP for metastatic bone pain in breast cancer patients. Eur J Nucl Med Mol Imaging 31. https://doi.org/10.1007/s00259-004-1539-4
Denis-Bacelar AM, Chittenden SJ, Dearnaley DP et al (2017) Phase I/II trials of 186Re-HEDP in metastatic castration-resistant prostate cancer: post-hoc analysis of the impact of administered activity and dosimetry on survival. Eur J Nucl Med Mol Imaging 44:620–629. https://doi.org/10.1007/s00259-016-3543-x
Kinuya S, Yokoyama K, Izumo M et al (2005) Locoreginal radioimmunotherapy with 186Re-labeled monoclonal antibody in treating small peritoneal carcinomatosis of colon cancer in mice in comparison with 131I-counterpart. Cancer Lett 219:41–48. https://doi.org/10.1016/j.canlet.2004.08.033
Jalilian AR, Beiki D, Hassanzadeh-Rad A et al (2016) Production and clinical applications of radiopharmaceuticals and medical radioisotopes in Iran. Semin Nucl Med 46:340–358. https://doi.org/10.1053/j.semnuclmed.2016.01.006
Knut L (2015) Radiosynovectomy in the Therapeutic Management of Arthritis. World J Nucl Med 14:10. https://doi.org/10.4103/1450-1147.150509
North AJ, Karas JA, Ma MT et al (2017) Rhenium and Technetium-oxo Complexes with Thioamide Derivatives of Pyridylhydrazine Bifunctional Chelators Conjugated to the Tumour Targeting Peptides Octreotate and Cyclic-RGDfK. Inorg Chem 56:9725–9741. https://doi.org/10.1021/acs.inorgchem.7b01247
Shegani A, Ischyropoulou M, Roupa I et al (2021) Synthesis and evaluation of new mixed “2 + 1” Re, 99mTc and 186Re tricarbonyl dithiocarbamate complexes with different monodentate ligands. Bioorg Med Chem 47:116373. https://doi.org/10.1016/j.bmc.2021.116373
Makris G, Kuchuk M, Gallazzi F et al (2019) Somatostatin receptor targeting with hydrophilic [99mTc/186Re]Tc/Re-tricarbonyl NODAGA and NOTA complexes. Nucl Med Biol 71:39–46. https://doi.org/10.1016/j.nucmedbio.2019.04.004
Makris G, Bandari RP, Kuchuk M et al (2021) Development and Preclinical Evaluation of 99mTc- and 186Re-Labeled NOTA and NODAGA Bioconjugates Demonstrating Matched Pair Targeting of GRPR-Expressing Tumors. Mol Imaging Biol 23:52–61. https://doi.org/10.1007/s11307-020-01537-1
Aranda-Lara L, Morales-Avila E, Luna-Gutiérrez MA et al (2020) Radiolabeled liposomes and lipoproteins as lipidic nanoparticles for imaging and therapy. Chem Phys Lipids 230. https://doi.org/10.1016/j.chemphyslip.2020.104934
Aliev RA, Kormazeva ES, Furkina EB et al (2020) Rhenium Radioisotopes: Production, Properties, and Targeted Delivery Using Nanostructures. Nanotechnologies Russ 15:428–436. https://doi.org/10.1134/S1995078020040023
Budak MG (2019) Determination of effective resonance energies for the185Re(n,ɣ)186Re and187Re(n,ɣ)188Re reactions by cadmium ratio method. Turkish J Phys 43:147–155. https://doi.org/10.3906/fiz-1808-19
Katabuchi T, Takebe K, Umezawa S et al (2018) Neutron capture cross section of 185Re leading to ground and isomer states of 186Re in the keV-neutron energy region. EPJ Web Conf 178:03005. https://doi.org/10.1051/epjconf/201817803005
Tárkányi F, Takács S, Szelecsényi F et al (2006) Excitation functions of proton induced nuclear reactions on natural tungsten up to 34 MeV. Nucl Instruments Methods Phys Res Sect B Beam Interact with Mater Atoms 252:160–174. https://doi.org/10.1016/j.nimb.2006.09.010
Khandaker MU, Uddin MS, Kim K et al (2008) Excitation functions of proton induced nuclear reactions on natW up to 40 MeV. Nucl Instruments Methods Phys Res Sect B Beam Interact with Mater Atoms 266:1021–1029. https://doi.org/10.1016/j.nimb.2008.02.037
Kambali I (2021) Cyclotron-based rhenium-186 production using proton beam of up to 50 MeV. J Phys Conf Ser 1825:012085. https://doi.org/10.1088/1742-6596/1825/1/012085
Khandaker MU, Nagatsu K, Minegishi K et al (2017) Study of deuteron-induced nuclear reactions on natural tungsten for the production of theranostic 186Re via AVF cyclotron up to 38 MeV. Nucl Instruments Methods Phys Res Sect B Beam Interact with Mater Atoms 403:51–68. https://doi.org/10.1016/j.nimb.2017.04.087
Wang J, Tao X, Kang M et al (2017) Evaluation of excitation function for 186 W(d,2n)186Re reaction. In: EPJ Web of Conferences. https://doi.org/10.1051/epjconf/201714602022
Duchemin C, Guertin A, Haddad F et al (2015) Cross section measurements of deuteron induced nuclear reactions on natural tungsten up to 34 MeV. Appl Radiat Isot 97:52–58. https://doi.org/10.1016/j.apradiso.2014.12.011
Aliev RA, Zagryadskiy VA, Kormazeva ES et al (2021) Measurement of 186 W(4He,p3n)186Re, 186 W(4He,pn)188Re, 186 W(4He, p)189Re reaction cross sections by 4He irradiation of 186 W target. At Energy 130:36–39. https://doi.org/10.1007/s10512-021-00770-3
Zagryadskii VA, Latushkin ST, Makoveeva KA et al (2020) Measurement of 186Re, 188Re, 189Re yield on 186 W target irradiation by 4He, 3He, 1H, and 2H. At Energy 128:162–165. https://doi.org/10.1007/s10512-020-00668-6
Moiseeva AN, Aliev RA, Kormazeva ES et al (2021) Cross sections of 3He-particle induced reactions on 186 W. Appl Radiat Isot 170. https://doi.org/10.1016/j.apradiso.2021.109609
Zagryadskiy VA, Kravets YM, Latushkin ST et al (2021) An apparatus for extraction of rhenium radioisotopes from an irradiated tungsten target. Instruments Exp Tech 64:615–618. https://doi.org/10.1134/S0020441221040254
Moustapha ME, Ehrhardt GJ, Smith CJ et al (2006) Preparation of cyclotron-produced 186Re and comparison with reactor-produced 186Re and generator-produced 188Re for the labeling of bombesin. Nucl Med Biol 33:81–89. https://doi.org/10.1016/j.nucmedbio.2005.09.006
Shigeta N, Matsuoka H, Osa A et al (1996) Production method of no-carrier-added 186Re. J Radioanal Nucl Chem 205:85–92. https://doi.org/10.1007/BF02040553
Gott MD, Ballard BD, Redman LN et al (2014) Radiochemical study of Re/W adsorption behavior on a strongly basic anion exchange resin. Radiochim Acta 102:325–332. https://doi.org/10.1515/ract-2013-2144
Fassbender ME, Ballard B, Birnbaum ER et al (2013) Proton irradiation parameters and chemical separation procedure for the bulk production of high-specific-activity 186gRe using WO3 targets. Radiochim Acta 101:339–346. https://doi.org/10.1524/ract.2013.2031
Zhang X, Li W, Fang K et al (1999) Excitation Functions for natW(p,xn)181–186Re reactions and production of no-carrier-added 186Re via 186 W(p,n)186Re reaction. Radiochim Acta 86:11–16. https://doi.org/10.1524/ract.1999.86.12.11
Zhang X, Li Q, Li W et al (2001) Production of no-carrier-added 186Re via deuteron induced reactions on isotopically enriched 186 W. Appl Radiat Isot 54:89–92. https://doi.org/10.1016/S0969-8043(00)00268-2
Horwitz EP, Dietz ML, Chiarizia R et al (1995) Separation and preconcentration of actinides by extraction chromatography using a supported liquid anion exchanger: application to the characterization of high-level nuclear waste solutions. Anal Chim Acta 310:63–78. https://doi.org/10.1016/0003-2670(95)00144-O
Snow M, Ward J (2020) Fundamental distribution coefficient data and separations using eichrom extraction chromatographic resins. J Chromatogr A 1620:460833. https://doi.org/10.1016/J.CHROMA.2019.460833
Zhang Z, Zhou G, Lin J et al (2017) Preconcentration and separation of 99Tc in groundwater by using TEVA resin. J Radioanal Nucl Chem 314:161–166. https://doi.org/10.1007/s10967-017-5425-5
Uchida S, Tagami K, Saito M (2003) Determination of rhenium traces in river water by Q-ICP-MS and HR-ICP-MS. J Radioanal Nucl Chem 255:329–333. https://doi.org/10.1023/A:1022556804570
Makishima A, Nakanishi M, Nakamura E (2001) A group separation method for Ruthenium, Palladium, Rhenium, Osmium, Iridium, and Platinum using their bromo complexes and an anion exchange resin. Anal Chem 73:5240–5246. https://doi.org/10.1021/ac010615u
Snow MS, Finck MR, Carney KP, Morrison SS (2017) Extraction chromatographic separations of tantalum and tungsten from hafnium and complex matrix constituents. J Chromatogr A 1484:1–6. https://doi.org/10.1016/J.CHROMA.2017.01.019
Lučaníková M, Kučera J, Šebesta F (2008) New extraction chromatographic material for rhenium separation. J Radioanal Nucl Chem 277:479–485. https://doi.org/10.1007/s10967-007-7153-8
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This work was done with the financial support of the National Research Center “Kurchatov Institute”, order № 2751 from 28.10.2021.
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Furkina, E.B., Moiseeva, A.N., Aliev, R.A. et al. Chromatographic separation of rhenium radioisotopes from irradiated tungsten cyclotron target. J Radioanal Nucl Chem 331, 4563–4568 (2022). https://doi.org/10.1007/s10967-022-08526-4
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DOI: https://doi.org/10.1007/s10967-022-08526-4