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The application value of 18F-Alfatide-RGD PET/CT in the preliminary diagnosis of patients with non-small cell lung cancer

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Abstract

To investigate the role of the positron emission tomography (PET) tracer 18F-Alfatide labeled dimerized-RGD (18F-Alfatide-RGD) in non-small cell lung cancer (NSCLC). Forty-eight NSCLC patients were retrospectively enrolled. Evaluation of diagnostic test was used to assess the diagnostic performance of 18F-Alfatide-RGD PET/CT. 18F-Alfatide-RGD PET/CT showed general consistency in diagnosis and pathologic results of primary foci in lung cancer, and high consistency in detection and pathologic results of patients with lymph node-positive and metastatic lymph nodes. 18F-Alfatide-RGD PET/CT in the initial diagnosis of NSCLC has a high sensitivity and specificity, contributing to accurate clinical staging and preoperative evaluation.

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Acknowledgements

We would like to acknowledge the everyone for their helpful contributions on this paper.

Funding

Key R&D Program of Shandong Province (No. 2016GSF201173).

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Author notes

  1. Huimin Guo and Jing Zhou are Co-first Authors.

Authors and Affiliations

  1. Department of Nuclear Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, NO. 324 Jingwu Road, Jinan, 250021, China

    Huimin Guo, Shuzhan Yao, Jun Li & Songtao Liu

  2. Department of Radiation Therapy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China

    Jing Zhou

  3. PET/CT Center of Imaging Department, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China

    Zheng Fu

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  1. Huimin Guo
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  4. Jun Li
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Each author has made an important scientific contribution to the study and has assisted with the drafting or revising of the manuscript.

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Correspondence to Songtao Liu.

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The ethic approval was obtained from the Ethic Committee of Shandong Provincial Hospital Affiliated to Shandong First Medical University.

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Guo, H., Zhou, J., Yao, S. et al. The application value of 18F-Alfatide-RGD PET/CT in the preliminary diagnosis of patients with non-small cell lung cancer. J Radioanal Nucl Chem 331, 4141–4148 (2022). https://doi.org/10.1007/s10967-022-08496-7

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  • DOI: https://doi.org/10.1007/s10967-022-08496-7

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