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Medical 15O production via the 16O(γ,n)15O reaction for blood flow examination

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Abstract

We propose a new scheme for producing medical 15O isotopes using a water target, for blood flow examination with Positron Emission Tomography. The 15O radioisotopes are produced via the 16O(γ,n)15O reaction in a water target. A simulation study has been carried out to determine the productivity of radioactive [15O]-water using bremsstrahlung γ–rays by a 40 MeV electron beam of 100 μA. The productivity of [15O]-water with an activity of 6.9 GBq was confirmed by a 10-min radiation exposure. Produced [15O]-water is easily and rapidly sent from the production site to a patient site through a transport tube.

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Acknowledgements

It is a great pleasure for us to acknowledge H. Iida and J. Hatazawa for stimulating discussion on the [15O]-water radiopharmaceuticals and its clinical PET applications. We would like to express our gratitude to M. Shepherd, S.E. Lapi, N. Takahashi, and Y. Kosuge to discuss the production of an activity of 15O. Finally, we are grateful to Y. Aiba of Kyocera Co. Ltd. for the discussion on the application of medical radioisotopes 15O.

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Authors and Affiliations

  1. Research Center for Nuclear Physics, Osaka University, Mihogaoka 10-1, Ibaraki, Osaka, 567-0047, Japan

    M. Fujiwara, M. Kurosawa & M. Tamura

  2. Department of Medical Physics, Faculty of Medicine, Kagawa University, 1760-1 Ikenobe, Miki-Cho, Kita-gun, Kagawa, 761-0793, Japan

    N. Kudomi

  3. R&D Center Kagoshima, KYOCERA Corporation, 1-4 Kokubu Yamashita-Cho, Kirishima-Shi, Kagoshima, 899-4312, Japan

    M. Nishimura

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  1. M. Fujiwara
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Correspondence to M. Fujiwara.

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Fujiwara, M., Kurosawa, M., Tamura, M. et al. Medical 15O production via the 16O(γ,n)15O reaction for blood flow examination. J Radioanal Nucl Chem 330, 141–148 (2021). https://doi.org/10.1007/s10967-021-07963-x

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