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Medical radioisotope 89Zr production with RFT-30 cyclotron

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Abstract

89Zr is an emerging radionuclide with promising application in nuclear medicine for the non-invasive diagnosis of various cancers with PET imaging. This paper would discuss optimization efforts in the production of 89Zr carried out at Accelerator Radioisotope Development Team, Korea Atomic Energy Research Institute. Optimized conditions reveal high production yields of 89Zr ~ 37 ± 1.4 MBq/µA using 89Y(p,n)89Zr, ~ 12.7 MeV of proton, and 35 µA using yttrium coin target with indigenously constructed 30 MeV Cyclotron (RFT-30). Besides, the production optimization, quality control, and biological behavior of [89Zr]Zr-oxalate, chloride and, DFO demonstrated promising results.

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Acknowledgements

This researchwas supported by the Nuclear R&D Program through the National Research Foundation of Korea, funded by the Ministry of Science, ICT, and Future Planning (2017M2A2A6A05016600 and 2021M2E7A1079112) and NTIS (2021), Republic of Korea.

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Authors and Affiliations

  1. Department, Accelerator Radioisotope Development Team, Korea Atomic Energy Research Institute, 29 Geumgu-gil, Jeongeup-So, Jeollabuk-Do, 56212, Republic of Korea

    Jun Young Lee, Min Goo Hur, Young Bae Kong, Eun Je Lee, Seung Dae Yang, Pyeong Seok Choi & Jeong Hoon Park

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  1. Jun Young Lee
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  2. Min Goo Hur
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  3. Young Bae Kong
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  4. Eun Je Lee
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Correspondence to Jeong Hoon Park.

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Lee, J.Y., Hur, M.G., Kong, Y.B. et al. Medical radioisotope 89Zr production with RFT-30 cyclotron. J Radioanal Nucl Chem 330, 455–460 (2021). https://doi.org/10.1007/s10967-021-07884-9

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