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Assessment of Re/[99mTc]Tc-cirsiliol as a potential radiotracer to detect melanoma tumor

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Abstract

The purpose of this study was to label a trihydroxyflavone with the name of cirsiliol (3’,4’,5-Trihydroxy-6,7-dimethoxyflavone) with Re/[99mTc]Tc. After that in vivo study in C57 mice with Xenograft melanoma tumor was done. Labeling was optimized, and radiochemical analysis was performed. The high radiochemical yield (> 97%) was achieved for cirsiliol which was stable up to 4 h. Rhenium-labeled cirsiliol characterized the complex formation. High tumor uptake was seen for [99mTc]Tc-cirsiliol (2.16 ± 0.23% ID/g) at 1 h post injection. Because of its ability to accumulate and identify tumors, [99mTc]Tc-cirsiliol has a potential to be considered as new radiotracer for melanoma tumor detecting.

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Acknowledgements

This research has been part of a Ph.D. thesis and supported by Shahid Beheshti University and Nuclear Science and Technology Research Institute, Tehran, Iran.

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Authors and Affiliations

  1. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran

    Maryam Ghalbi Ahangari & Mahdi Moridi Farimani

  2. Radiation Applications Research School, Nuclear Science and Technology Research Institute, Tehran, Iran

    Mostafa Erfani

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  1. Maryam Ghalbi Ahangari
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  2. Mahdi Moridi Farimani
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  3. Mostafa Erfani
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Correspondence to Mostafa Erfani.

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Ghalbi Ahangari, M., Moridi Farimani, M. & Erfani, M. Assessment of Re/[99mTc]Tc-cirsiliol as a potential radiotracer to detect melanoma tumor. J Radioanal Nucl Chem 328, 847–855 (2021). https://doi.org/10.1007/s10967-021-07713-z

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