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Studies on the preparation and characterization of 90Y-EGMP patches designed for superficial skin brachytherapy

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Abstract

This paper describes a facile approach for preparation of 90Y-EGMP sources for their potential use in treatment of superficial maladies like keloids and skin cancers. Conditions for impregnation of 90Y into EGMP films were optimized and characterization of membranes using state of the art SEM, EDX and radiochromic film based autoradiography was accomplished. Leachability of 90Y from radioactive patches in aqueous and saline medium was less than 0.01%. Sources exhibited removable contamination well within the permissible levels thereby proving their safety for intended use. Upto 185 MBq/cm2 of 90Y could be impregnated in custom shaped sources in a reproducible manner.

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Acknowledgements

Authors wish to thank Dr. P.K. Pujari, Director, Radiochemistry and Isotope Group for his encouragement and support. Our thanks are due to Dr. Ashutosh Dash former Head, Radiopharmaceuticals Division for providing necessary support for perusal of this work. Thanks are due to Dr. Rubel Chakraborty of our Division for providing radiotracer required for the research work. Our sincere thanks are due to Dr. Pankaj Tandon formerly associated with Radiological Physics and Advisory Division of our institute for providing support in GAF Chromic film measurements.

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Authors and Affiliations

  1. Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India

    Sanjay Kumar Saxena & Yogendra Kumar

  2. Radiochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India

    Ashok K. Pandey

  3. Technical Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India

    K. P. Muthe

Authors
  1. Sanjay Kumar Saxena
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  2. Yogendra Kumar
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  3. Ashok K. Pandey
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  4. K. P. Muthe
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Contributions

Sanjay Kumar Saxena: Conceptualization, Methodology,Writing, Reviewing and Editing. Yogendra Kumar: Experimental investigations. Ashok K. Pandey: Preparation of EGMP membranes. K.P. Muthe: Surface Characterization of EGMP membranes.

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Correspondence to Sanjay Kumar Saxena.

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Saxena, S.K., Kumar, Y., Pandey, A.K. et al. Studies on the preparation and characterization of 90Y-EGMP patches designed for superficial skin brachytherapy. J Radioanal Nucl Chem 328, 387–396 (2021). https://doi.org/10.1007/s10967-021-07657-4

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  • DOI: https://doi.org/10.1007/s10967-021-07657-4

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