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Predicting pleural metastasis by detecting CD55 using an ultrasound-enhanced scintillation proximity assay

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Abstract

We used an ultrasound-enhanced scintillation proximity assay to accurately determine the levels of complement decay-accelerating factor (CD55) for the early detection and assessment of the progression of pleural metastatic lung cancer. We found that the expression of CD55 in metastatic tumor tissues is 2.8 times higher than that in the serum at the early stages. We also found that the concentration of CD55 in serum decreases with the progression of metastasis. These results suggest that CD55 is a potential biomarker for the prediction of pleural metastatic lung cancer.

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Acknowledgements

This work was supported by Korea Atomic Energy Research Institute: Development of Radioisotope Production and Application Technology [524430-20].

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Authors and Affiliations

  1. Radioisotope Research Division, Korea Atomic Energy Research Institute (KAERI), Daejeon, 305-353, Republic of Korea

    So-Young Lee, Jae-Cheong Lim, Eun-Ha Cho & Sung-Hee Jung

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  1. So-Young Lee
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  2. Jae-Cheong Lim
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  3. Eun-Ha Cho
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  4. Sung-Hee Jung
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Correspondence to So-Young Lee.

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Lee, SY., Lim, JC., Cho, EH. et al. Predicting pleural metastasis by detecting CD55 using an ultrasound-enhanced scintillation proximity assay. J Radioanal Nucl Chem 327, 707–712 (2021). https://doi.org/10.1007/s10967-020-07559-x

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  • DOI: https://doi.org/10.1007/s10967-020-07559-x

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