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Radiochemical separation of no-carrier-added 186Re from proton irradiated tungsten target

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Abstract

Rhenium-186 [t½ = 3.7 d, 1.07 MeV β−-particles, 137 keV γ-ray] is an emerging radioisotope which holds tremendous potential in preparation of theranostic radiopharmaceuticals. This radioisotope was produced in a no-carrier-added form by irradiation of enriched 186W target via 186W(p, n) 186Re reaction in a pelletron. A facile radiochemical separation procedure based on selective solvent extraction in methylethyl ketone medium followed by column chromatography using mesoporous alumina sorbent has been developed to obtain 186Re in a form suitable for radiopharmaceutical preparation. This approach is expected to promote widespread utilization of this radioisotope for the benefit of cancer patients.

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Acknowledgements

The authors are thankful to Dr. P.K. Pujari, Director, Radiochemistry and Isotope Group, Bhabha Atomic Research Centre for his encouragement and support. Thanks are due to Dr. K. P. Muthe and Dr. Ajay Singh of Technical Physics Division, Bhabha Atomic Research Centre for preparation of the target. Analytical Chemistry Division, Bhabha Atomic Research Centre is gratefully acknowledged for ICP-AES analyses of samples. All staff members of BARC-TIFR pelletron facility are gratefully acknowledged for their support during the irradiation process.

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Authors and Affiliations

  1. Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India

    Ramu Ram, Rubel Chakravarty, Sachin Jadhav, Sudipta Chakraborty, K. C. Jagadeesan, S. V. Thakare & Ashutosh Dash

  2. Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, India

    Rubel Chakravarty, Sudipta Chakraborty & Ashutosh Dash

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  1. Ramu Ram
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  2. Rubel Chakravarty
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  3. Sachin Jadhav
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  5. K. C. Jagadeesan
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  6. S. V. Thakare
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  7. Ashutosh Dash
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Correspondence to Rubel Chakravarty.

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Ram, R., Chakravarty, R., Jadhav, S. et al. Radiochemical separation of no-carrier-added 186Re from proton irradiated tungsten target. J Radioanal Nucl Chem 325, 875–883 (2020). https://doi.org/10.1007/s10967-020-07207-4

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  • DOI: https://doi.org/10.1007/s10967-020-07207-4

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